Registration Dossier
Registration Dossier
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EC number: 253-506-0 | CAS number: 37439-34-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 11 May to 14 May 2010
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD guideline 431
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium 3,5,6-trichloropyridin-2-olate
- EC Number:
- 253-506-0
- EC Name:
- Sodium 3,5,6-trichloropyridin-2-olate
- Cas Number:
- 37439-34-2
- Molecular formula:
- C5HCl3NONa
- IUPAC Name:
- sodium 3,5,6-trichloropyridin-2-olate
- Details on test material:
- - Name of test material (as cited in study report): 2(1H)-pyridinone, 3,5,6-trichloro, sodium salt
- Physical state: white powder
- Lot/batch No.: 2010040701
- Storage condition of test material: app. 4°C in the dark
Constituent 1
Test animals
- Species:
- other: Episkin model kit 0.38 cm2
Results and discussion
In vivo
- Other effects:
- The MTT solution contaning the test material did not turn blue/purple. THis was taken to indicate that the test material did not reduce MTT.
Any other information on results incl. tables
| Material | Exposure period | Mean OD540 of duplicate tissues | Relative mean viability (%) |
| Negative Control Material | 240 minutes | 0.138 | 100 |
| Positive Control Material | 240 minutes | 0.013 | 9.4 |
| Test Material | 240 minutes | 0.274 | 198.6 |
| 60 minutes | 0.322 | 233.3 | |
| 3 minutes | 0.239 | 173.2 |
Applicant's summary and conclusion
- Interpretation of results:
- other: non-corrosive
- Remarks:
- Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The test material was considered to be non-corrosive to the skin.
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