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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from authoritative database.

Data source

Referenceopen allclose all

Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
Reference Type:
other: Secondary Literature
Title:
Acute oral toxicity of test chemical in rats
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance data base), 2018
Reference Type:
review article or handbook
Title:
Acute oral toxicity of test chemical
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
To determine the Acute Oral toxicity of test chemical in rats.
GLP compliance:
not specified
Test type:
other: not specified
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trichloroacetyl chloride
EC Number:
200-926-7
EC Name:
Trichloroacetyl chloride
Cas Number:
76-02-8
Molecular formula:
C2Cl4O
IUPAC Name:
trichloroacetyl chloride
Test material form:
liquid
Details on test material:
UPAC name: 2,2,2-trichloroacetyl chloride
Mol. formula: C2Cl4O
Molecular Weight:
181.833 gm/mol
Smiles:
C(C(=O)Cl)(Cl)(Cl)Cl
InChI: 1S/C2Cl4O/c3-1(7)2(4,5)6

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
600 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
600 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No data available
Mortality:
50% mortality observed at 600 mg/kg bw dose level.
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The LD50 value for test chemical was observed to be 600 mg/kg bw when administered to rats via oral route.
Executive summary:

Acute oral toxicity study was performed on rats to determine the toxic nature of test chemical. A LD50 value of 600 mg/kg bw was observed when the test chemical was administered to rats via oral route. Thus indicating that the test chemical can be classified as 'Acute oral Category 4' according to the CLP regulation.