Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: Annex V (B1)
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test animals

Species:
other: Rat(Sprague-Dawley)

Administration / exposure

Vehicle:
other: The test material was ground to a fine powder using a mortar and pestle, and freshly prepared as required, as a suspension at the appropriate concentration in 0.5% gum tragacanth.

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Male: 200 mg/kg bw; Number of animals: 1; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 0
Female: 200 mg/kg bw; Number of animals: 1; Number of deaths: 0
Clinical signs:
other: Signs of toxicity related to dose levels: Clinical signs of toxicity were hunched posture and pilo- erection in two males and two females. The effects were noted 1, 2 and 4 hours and 1, 2 and 3 days after treatment. All animals showed expected gai
Gross pathology:
Effects on organs:
No abnormalities were noted at necropsy of animals killed
at the end of the study period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU