Registration Dossier
Registration Dossier
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EC number: 441-420-8 | CAS number: 113889-23-9
Endpoint summary
Administrative data
Description of key information
Bioaccumulation test on aquatic species is based on the available information (log Kow and calculated BCF values). The BCF for aquatic organisms was calculated using the QSAR of Veith et al.(1979), incorporated in the EUSES model, using the log Kow of 4.48 results in a BCF of 232 l/kg wwt
The BCF in earthworms was estimated with the equation from Jager (1998) which is incorporated in the EUSES model and is applicable to substances with a log Kow value ranging from 1-8: BCFworm = (Fwaterworm + Flipidworm*Kow)/RHO worm where Fwaterworm = 0.84, Flipidworm = 0.012 and RHO worm = 1 kg ww/l. Entering the log Kow value of 4.48 for the substance results in a BCFearthworm of 363 l/kg ww (earthworm).
The bioaccumulation in air-breathing organisms is considered negligible because Cyclobutanate is fully degraded in the STP after 28 days into CO2 (34%) and Cycla-alcohol (66%) showing complete de-esterification, resulting in the substance completely primary biodegraded non-P. This de-esterifcation is a common pathway due to the abundant presence of carboxylesterases. The Cycla-alcohol is a secondary alcohol which will be glucuronidated during Phase 2 metabolism and thereafter excreted in the kidneys as is seen in the repeated dose toxicity studies (for references see Toxico-kinetic section). In addition, the DT50 is calculated to be 0.34 day by BCFBAF.
Additional information
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