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EC number: 404-600-7 | CAS number: 129009-88-7 EVERZOL ORANGE GR; ORANGE HF-SNK; REAKTIV ORANGE FD 19969 FW
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- August 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances)
- Deviations:
- no
- Principles of method if other than guideline:
- No
- GLP compliance:
- yes
- Medium:
- standard fat
- Solubility:
- < 0.004 mg/100 g solvent
- Temp.:
- 37 °C
- Test substance stable:
- yes
- Conclusions:
- Based on the above data the fat solubility of the test substance (mean) is < 0.0036 mg per 100 g fat at 37 deg C (not corrected). RSD = 0.74%
- Executive summary:
The fat solubility of the test substance was determined according OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances). Based on the results the fat solubility of the test substance (mean) is < 0.0036 mg per 100 g fat at 37 deg C (not corrected). RSD = 0.74%
Reference
The ratio of the test substance per 100 g fat was referred to the concentration of the lowest calibration standard (detection limit).
For evaluation of the result one has to take into account that the spectrometric measurements only include organic components showing absorption at the quantification wavelength.
Experiment |
Pre-saturation |
Stirring time at 37°C (h) |
Mass ratio Dissolved test substance/fat (100 mg/100g) |
|
Stirring time (h) |
Temperature (°C) |
|||
1 |
3.0 |
30 |
3 |
< 0.00361 |
2 |
3.0 |
30 |
3 |
< 0.00366 |
3 |
3.0 |
30 |
27 |
< 0.03361 |
4 |
3.0 |
30 |
27 |
< 0.00365 |
5 |
3.0 |
50 |
3 |
< 0.00361 |
6 |
3.0 |
50 |
3 |
< 0.00361 |
7 |
3.0 |
50 |
27 |
< 0.00367 |
8 |
3.0 |
50 |
27 |
< 0.00366 |
Description of key information
The fat solubility of the test substance (mean) is < 0.0036 mg per 100 g fat at 37° C (not corrected). RSD = 0.74%
Key value for chemical safety assessment
- Solubility in mg/100g standard fat:
- 0.004
- At the temperature of:
- 37 °C
Additional information
The fat solubility of the test substance was determined according OECD Guideline 116 (Fat Solubility of Solid and Liquid Substances). Based on the results the fat solubility of the test substance (mean) is < 0.0036 mg per 100 g fat at 37° C (not corrected). RSD = 0.74% (Praschak I and Mühlberger B, 2000).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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