Registration Dossier
Registration Dossier
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EC number: 202-761-6 | CAS number: 99-51-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- No information
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource); Kawai,A, Goto,S, Matsumoto,Y And Matsushita,H; Mutagenicity of Aliphatic Aand Aromatic Nitro Compounds; Sangyo Igaku 29(1):34-55, 1987
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is taken from Actor database.
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-nitro-o-xylene
- EC Number:
- 202-761-6
- EC Name:
- 4-nitro-o-xylene
- Cas Number:
- 99-51-4
- Molecular formula:
- C8H9NO2
- IUPAC Name:
- 4-nitro-o-xylene
- Details on test material:
- Substance Name : 4-nitro-o-xylene
Molecular Formula : C8H9NO2
Physical state : Liquid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with
- Metabolic activation system:
- Rat, Liver, S-9, Kanechlor 500
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Remarks on result:
- other: other: Rat, Liver, S-9, Kanechlor 500
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Gene mutation studies for 4-nitro-oxylenol conducted on Salmonella typhimurium strains TA 100 and TA 98 with metabolic activation (Rat, Liver, S-9, Kanechlor 500) showed negatve results. Based on this, this substance is not likely to cause genotixic effects. - Executive summary:
Gene mutation studies for 4-nitro-oxylenol conducted on Salmonella typhimurium strains TA 100 and TA 98 with metabolic activation (Rat, Liver, S-9, Kanechlor 500) showed negatve results. Based on this, this substance is not likely to cause genotixic effects.
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