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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
No information
Year:
2011
Bibliographic source:
ACToR (Aggregated Computational Toxicology Resource); Kawai,A, Goto,S, Matsumoto,Y And Matsushita,H; Mutagenicity of Aliphatic Aand Aromatic Nitro Compounds; Sangyo Igaku 29(1):34-55, 1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is taken from Actor database.
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
4-nitro-o-xylene
EC Number:
202-761-6
EC Name:
4-nitro-o-xylene
Cas Number:
99-51-4
Molecular formula:
C8H9NO2
IUPAC Name:
4-nitro-o-xylene
Details on test material:
Substance Name : 4-nitro-o-xylene
Molecular Formula : C8H9NO2
Physical state : Liquid

Method

Species / strain
Species / strain / cell type:
S. typhimurium TA 98
Additional strain / cell type characteristics:
not specified
Metabolic activation:
with
Metabolic activation system:
Rat, Liver, S-9, Kanechlor 500

Results and discussion

Test results
Species / strain:
S. typhimurium TA 98
Metabolic activation:
with
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Remarks on result:
other: other: Rat, Liver, S-9, Kanechlor 500
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Gene mutation studies for 4-nitro-oxylenol conducted on Salmonella typhimurium strains TA 100 and TA 98 with metabolic activation (Rat, Liver, S-9, Kanechlor 500) showed negatve results. Based on this, this substance is not likely to cause genotixic effects.
Executive summary:

Gene mutation studies for 4-nitro-oxylenol conducted on Salmonella typhimurium strains TA 100 and TA 98 with metabolic activation (Rat, Liver, S-9, Kanechlor 500) showed negatve results. Based on this, this substance is not likely to cause genotixic effects.

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