Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 209-963-3 | CAS number: 599-04-2
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 24.08.2009 - 03.11.2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: According to guideline under GLP
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Principles of method if other than guideline:
- Not relevant
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- α-hydroxy-β,β-dimethyl-γ-butyrolactone
- EC Number:
- 209-963-3
- EC Name:
- α-hydroxy-β,β-dimethyl-γ-butyrolactone
- Cas Number:
- 599-04-2
- Molecular formula:
- C6H10O3
- IUPAC Name:
- (3R)-3-hydroxy-4,4-dimethyloxolan-2-one
- Reference substance name:
- 209 963 3
- IUPAC Name:
- 209 963 3
- Details on test material:
- - Name of test material (as cited in study report): R-Pantolactone
- Physical state: solid
- Analytical purity: 99.6%
- Stability under test conditions: yes
- Storage condition of test material: RT
Constituent 1
Constituent 2
Results and discussion
Water solubility
- Water solubility:
- 540.2 g/L
- Temp.:
- 21.8 °C
- pH:
- 3.9
Any other information on results incl. tables
No further remarks
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): soluble (1000-10000 mg/L)
During this study the water solubility of R-Pantolactone at room temperature was determined
using a simplified flask method and was found to be > 540.2 g/L at 21.8 OC and a pH of 3.9 - Executive summary:
The determination of the water solubility of R-Pantolactone was performed according to the OECD Guideline No. 105 "Water Solubility" (1995) using a simplified flask method.
After mixing a total of about 5.2 g of test item in 5 mL of water (which corresponds to a visual
determined solubility of > 1.0 kdL) the test item was completely dissolved. It was not possible
to prepare a saturated solution before obtaining a 1:l mixture, therefore, the water solubility of
R-Pantolactone might be higher as determined in this test. The determination of the
concentration in the above mentioned test item / water mixture was confirmed by HPLC.
Details of the preliminary test are given in Table 1.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
