Registration Dossier
Registration Dossier
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EC number: 700-742-1 | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Half-lives (DT50) at 25 °C:
- t1/2 (pH4) > 1 year
- t1/2 (pH7) = 280 days
- t1/2 (pH9) = 68.4 hours
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 280 d
- at the temperature of:
- 25 °C
Additional information
Concerning hydrolysis, no experimental data are available of RAV 7MC (EC 700-742-1). In order to fulfill this endpoint under REACH, read-across was used (diallyl 2,2'-oxydiethyl dicarbonate, EC 205-528-7).
In an experiment, conducted according to OECD Guideline 111, it was found that the higher the surrounding pH, the faster the hydrolysis rate, whereas half-lives (at 25 °C) are decreasing with increasing pH values (Mullee, 2005). The values obtained at pH 4, 7 and 9 were described as followed: more than 1 year, 280 days and 68.4 hours, respectively. At pH 7 and 9 graphs of the common logarithm of the concentration (g/L) versus time (hours) were plotted and the rate constant and half-life were calculated. By plotting the natural logarithm of the rate constants against the reciprocal of the temperature (K), the rate constant and half-lives at 25 °C were obtained by either inter- or extrapolation. The sample solutions at pH 4 were maintained at 50 +/- 0.5 °C for a period of 120 hours, whereby less than 10 % hydrolysis was measured after 5 days, which is considered as equivalent to a half-life greater than 1 year at 25 °C. Sample solutions at pH 7 were maintained at the same temperatures for a period of 360 hours. The extent of hydrolysis after 360 hours indicated that a further test (with solutions being maintained at 60 and 70 +/- 0.5 °C) was required to estimate the rate constant and half-life, resulting in a half-live of 69 h at 60 °C and 23.7 h at 70 °C. Due to the anticipated rapid hydrolysis at pH 9, solutions were maintained at 20 °C and 30 +/- 0.5 °C. The half-lives were found at 133 h and 36 h, respectively.
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