Registration Dossier

Administrative data

Endpoint:
nanomaterial dustiness
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
test procedure in accordance with national standard methods
Remarks:
according to DIN EN 17199-3

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2020
Report date:
2020

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: DIN EN 17199-3
Version / remarks:
measurement of dustiness of bulk materials that contain or release respirable NOAA or other respirable particles - Part 3: Continuous drop method
Deviations:
yes
Remarks:
test conditions (temperature, humidity) due to laboratory environment; 1 meaurement performed
GLP compliance:
no
Type of method:
continuous drop
Sampling:
The test material was used without further treatment (e.g. drying). 37.3 g (160.0 cm3) test material are used for the measurement, dosing rate: 3.7 g/min

Test material

Constituent 1
Chemical structure
Reference substance name:
Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate
EC Number:
249-955-7
EC Name:
Dimethyl 5-[[1-[[(2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)amino]carbonyl]-2-oxopropyl]azoterephthalate
Cas Number:
29920-31-8
Molecular formula:
C21H19N5O7
IUPAC Name:
1,3-dimethyl 5-[(E)-2-{2-oxo-1-[(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-5-yl)carbamoyl]propyl}diazen-1-yl]benzene-1,3-dicarboxylate
Test material form:
solid: nanoform

Results and discussion

Dustiness indexopen allclose all
Key result
Mean:
636 777.46 other: 1/mg
Remarks on result:
other: dustiness index as number of airborne particles per mg in the nanoscale (10 nm - 100 nm)
Mean:
44 814.72 other: N/cm3
Remarks on result:
other: number of airborne nanoparticles per cm3

Any other information on results incl. tables

meaurment duration: 10 min, temperature: 15°C, rel. air humidity 55 %

The cleaned, almost particle-free air had a total particle count of 177 particles/cm3 in the range of 10 nm - 417 nm, the nanoscale fraction (10 - 100 nm) contained 127 particles/cm3.

table 1: summary SMPS (sanning mobility particle sizer)

Range [nm]

Mean [nm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

10 - 100

66.45

44814.72

636777.46

1061.30

100 - 417

141.76

46352.90

658633.74

1097.72

10 - 417

104.74

91167.62

1295411.20

2159.02

ICD: dustiness index as number of airborne particles per mg

ECD: emission rate as number of particles per mg per second

mean: average particle diameter in nm

N: number of airborne particles

table 2: summary OPS (optical particle sizer)

Range [µm]

Mean [µm]

Concentration [N/cm3]

ICD[1/mg]

ECD[1/mg x s]

0.3 - 10

5.18

60.35

857.52

1.43

Applicant's summary and conclusion

Executive summary:

The dusting behaviour of the test material was investigated using DIN EN 17199 -3: 2019 -12 "workplace exposure - measurement of dustiness of bulk materials that contain or release respirable nano objects and their aggregates and agglomerates or other respirable particles- Part 3: Continuous drop method".

The dust released by the falling test material was measured by a scanning mobility particle sizer (SMPS, 10 - 417 nm) and an optical particle sizer (3 - 10 µm). The counterflow was provided by cleaned, almost particle-free air.

The SMPS counted 91167.62 airborne particles per cm3 (44814.72 particles in the nanoscale (10 - 100 m) ) corresponding to a dustiness index of 1295411.20 airborne particles per mg (636777.46 in the nanoscale (10 - 100 nm)) . The mean size of the nanoparticles was 66.45 nm, the mean size of particles in the range 10 - 417 nm was 104.74 nm.

The OPS (0.3 - 10 µm) counted 60.35 particles per cm3 corresponding to a dustiness index of 857.52 particles per mg. The mean size of the particles was 5.18 µm.