Registration Dossier
Registration Dossier
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EC number: 229-929-1 | CAS number: 6843-66-9
Endpoint summary
Administrative data
Description of key information
Buehler test (OECD TG 406, GLP): not sensitizing
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In the key study to assess skin sensitization a Buehler test according OECD TG 406 and in compliance with GLP was performed (Hüls AG, 1995d). Female Dunkin Hartley guinea pigs were treated (20/10 control/test group) thrice with 300 µl of the test substance every 7 days during the indu ction period. The test substance was applied undiluted for 6 hours under occlusive conditions. In a pretest the substance was found to be not irritating when applied undiluted. Two weeks after the last induction one challenge was performed in the same way as the induction procedure. 30 and 52 hours after the start of the challenge the skin reactions were scored. No reactions were observed at any time point and in any animal. In conclusion, the test substance is considered not to be a skin sensitizer under the applied conditions.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The available data on skin sensitisation of the registered substance do not meet the criteria for classification according to Regulation 1272/2008 or EU Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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