Registration Dossier
Registration Dossier
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EC number: 203-533-9 | CAS number: 107-93-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Remarks:
- Study performed prior to implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- trans-crotonic acid
- EC Number:
- 203-533-9
- EC Name:
- trans-crotonic acid
- Cas Number:
- 107-93-7
- Molecular formula:
- C4H6O2
- IUPAC Name:
- but-2-enoic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- body weight: 94-146 g
TEST ANIMALS
- Fasting period before study: yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sesame oil
- Details on oral exposure:
- no data
- Doses:
- 1250; 2000; 2500; 3200; 5000 mg/kg bw
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 days
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 610 mg/kg bw
- Mortality:
- yes, after 15-210 minutes
- Clinical signs:
- other: decedents: show imbalance and narcosis prior to death
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral toxicity (LD50) of crotonic acid in female wistar rats was determined to be 2610 mg/kg bw under the test conditions.
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