Registration Dossier
Registration Dossier
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EC number: 939-705-1 | CAS number: 2867-59-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
In this study the test item 3-Amino-butan-1-ol was assessed for its skin sensitizing potential using the Local Lymph Node Assay (LLNA, OECD 429 ) in mice. Test item solution at different concentrations was prepared in the vehicle DMF. For this purpose a local lymph node assay was performed using test item concentrations of 0.25, 0.5 and 1% (w/w). The highest concentration tested was the highest concentration that could be achieved whilst avoiding systemic toxicity and excessive local skin irritation. In this study Stimulation Indices (S.I.) of 1.21, 1.28 and 1.69 were determined with the test item at concentrations of 0.25, 0.5 and 1% (w/w) in DMF, respectively. The test item 3-Amino-butan-1-ol was thus not a skin sensitizer under the test conditions of this study. [BASF, 2014]
Migrated from Short description of key information:
LLNA: not sensitizing
Justification for selection of skin sensitisation endpoint:
only one study available
Justification for classification or non-classification
No need for classification according to Annex VI of Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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