Registration Dossier
Registration Dossier
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EC number: 406-760-3 | CAS number: 42221-52-3 2,3,4,5-TETRACHLORBENZOYLCHLORID
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: 84/449/EWG, B.12 (Mikrokerntest)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 2,3,4,5-tetrachlorobenzoylchloride
- EC Number:
- 406-760-3
- EC Name:
- 2,3,4,5-tetrachlorobenzoylchloride
- Cas Number:
- 42221-52-3
- Molecular formula:
- C7HCl5O
- IUPAC Name:
- 2,3,4,5-tetrachlorobenzoyl chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- other: mus, NMRI
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- Maisöl
- No. of animals per sex per dose:
- Male: 1000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 1000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Male: 1000 mg/kg; No. of animals: 5; Sacrifice time: 72 hours
Female: 1000 mg/kg; No. of animals: 5; Sacrifice times: 24 hours
Female: 1000 mg/kg; No. of animals: 5; Sacrifice times: 48 hours
Female: 1000 mg/kg; No. of animals: 5; Sacrifice times: 72 hours
Results and discussion
Test results
- Sex:
- male/female
- Genotoxicity:
- negative
- Toxicity:
- yes
- Remarks:
- (Doses producing toxicity: 1000 mg/kg)
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Observations:
Klinische Symptome; letale Effekte; cytotoxische Effekte
"ENGLISH"
Clinical symptoms: lethal effects, cytotoxic effects
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
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