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EC number: 254-447-3 | CAS number: 39430-51-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05 August - 20 August 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- and EU Method B.1 tris directive 2004/73/EC (Acute Oral Toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Groupe Interministeriel des Produits Chimiques
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Acetic acid, chromium salt, basic
- EC Number:
- 254-447-3
- EC Name:
- Acetic acid, chromium salt, basic
- Cas Number:
- 39430-51-8
- Molecular formula:
- Crx(OH)y(CH3COO)z, where y= 2 - 8, y + z =3x
- IUPAC Name:
- chromium(3+) acetate dihydroxide
- Details on test material:
- - Name of test material (as cited in study report): Chromium (III) acetate
- Substance type: green powder
- Physical state: solid
- Analytical purity: > 95%
- Lot/batch No.: 100014379
- Expiration date of the lot/batch: 03 July 2009
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage JANVIER, Le Genest St Isle, France
- Age at study initiation: 8 weeks
- Weight at study initiation: 189 - 200 g
- Fasting period before study: food was removed one day prior to dosing
- Housing:by groups of three in solid-bottomed clear polycarbonate cages with a stainless steel mesh lid. Each cage contained sawdust bedding which was changed at least 2 times a week. Each cage was installed in conventional air conditioned animal husbandry
- Water (e.g. ad libitum): tap water from public distribution system
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 24
- Humidity (%): 42 - 67
- Air changes (per hr): at least ten changes
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 mL/kg body weight - Doses:
- single dose of 2000 mg/kg body weight
- No. of animals per sex per dose:
- 6 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: daily observations, weighing at days 0, 2, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- No deaths occured.
- Clinical signs:
- other: No clinical signs observed.
- Gross pathology:
- No treatment related changes.
Any other information on results incl. tables
Table: Clinical observations (N = normal, No = none)
Observations: |
Females |
|||||
T0 + 30 min. T0 + 1 Hour T0 + 3 Hours T0 + 4 Hours |
Rf |
Rf |
Rf |
Rf |
Rf |
Rf |
1100 |
1101 |
1102 |
1106 |
1107 |
1108 |
|
Spontaneous activity |
N |
N |
N |
N |
N |
N |
Preyer’s reflex (noise) |
N |
N |
N |
N |
N |
N |
Respiratory rate |
N |
N |
N |
N |
N |
N |
Convulsions |
No |
No |
No |
No |
No |
No |
Tremors |
No |
No |
No |
No |
No |
No |
Body temperature |
N |
N |
N |
N |
N |
N |
Muscle tone |
N |
N |
N |
N |
N |
N |
Palpebral opening |
N |
N |
N |
N |
N |
N |
Pupil appearance |
N |
N |
N |
N |
N |
N |
Salivation |
N |
N |
N |
N |
N |
N |
Lachrymation |
N |
N |
N |
N |
N |
N |
Righting reflex |
N |
N |
N |
N |
N |
N |
Back hair appearance |
N |
N |
N |
N |
N |
N |
Mortality |
0 |
0 |
0 |
0 |
0 |
0 |
Remarks |
None |
None |
Table: Clinical observations continued (N = normal, No = none)
Observations: |
Females |
|||||
D1 to D14 |
Rf |
Rf |
Rf |
Rf |
Rf |
Rf |
1100 |
1101 |
1102 |
1106 |
1107 |
1108 |
|
Spontaneous activity |
N |
N |
N |
N |
N |
N |
Preyer’s reflex (noise) |
N |
N |
N |
N |
N |
N |
Respiratory rate |
N |
N |
N |
N |
N |
N |
Convulsions |
No |
No |
No |
No |
No |
No |
Tremors |
No |
No |
No |
No |
No |
No |
Body temperature |
N |
N |
N |
N |
N |
N |
Muscle tone |
N |
N |
N |
N |
N |
N |
Palpebral opening |
N |
N |
N |
N |
N |
N |
Pupil appearance |
N |
N |
N |
N |
N |
N |
Salivation |
N |
N |
N |
N |
N |
N |
Lachrymation |
N |
N |
N |
N |
N |
N |
Righting reflex |
N |
N |
N |
N |
N |
N |
Back hair appearance |
N |
N |
N |
N |
N |
N |
Mortality |
0 |
0 |
0 |
0 |
0 |
0 |
Remarks |
None |
None |
Table: Body weight and weight gain in grams
Females |
D0 |
D2 |
D2-D0 |
D7 |
D7-D0 |
D14 |
D14-D0 |
Rf 1100 |
189 |
205 |
16 |
225 |
36 |
240 |
51 |
Rf 1101 |
193 |
215 |
22 |
236 |
43 |
264 |
71 |
Rf 1102 |
195 |
226 |
31 |
228 |
33 |
264 |
69 |
Rf 1106 |
190 |
213 |
23 |
213 |
41 |
241 |
51 |
Rf 1107 |
200 |
223 |
23 |
243 |
43 |
258 |
58 |
Rf 1108 |
198 |
217 |
19 |
231 |
33 |
253 |
55 |
Mean |
194.2 |
216.5 |
22.3 |
232.3 |
38.2 |
253.3 |
59.2 |
Standard deviation |
4.4 |
7.5 |
5.0 |
6.4 |
4.8 |
10.8 |
8.8 |
Table: necropsy data females Rf1100 - Rf1102 (X = Euthanasia, at term; N.t.r = nothing to report)
Observed organs |
Results |
|
Oesophagus |
X |
N.t.r. |
Stomach |
X |
N.t.r. |
Duodenum |
X |
N.t.r. |
Jejunum |
X |
N.t.r. |
Ileon |
X |
N.t.r. |
Caecum |
X |
N.t.r. |
Colon |
X |
N.t.r. |
Rectum |
X |
N.t.r. |
Spleen |
X |
N.t.r. |
Liver |
X |
N.t.r. |
Thymus |
X |
N.t.r. |
Trachea |
X |
N.t.r. |
Lungs |
X |
N.t.r. |
Heart |
X |
N.t.r. |
Kidneys |
X |
N.t.r. |
Urinary Bladder |
X |
N.t.r. |
Ovaries |
X |
N.t.r. |
Uterus |
X |
N.t.r. |
Treatment Area |
- |
- |
Adrenals |
X |
N.t.r. |
Pancreas |
X |
N.t.r. |
Particulars: none |
Table: necropsy data females Rf1106 - 1108 (X = Euthanasia, at term; N.t.r. = nothing to report)
Observed organs |
Results |
|
Oesophagus |
X |
N.t.r. |
Stomach |
X |
N.t.r. |
Duodenum |
X |
N.t.r. |
Jejunum |
X |
N.t.r. |
Ileon |
X |
N.t.r. |
Caecum |
X |
N.t.r. |
Colon |
X |
N.t.r. |
Rectum |
X |
N.t.r. |
Spleen |
X |
N.t.r. |
Liver |
X |
N.t.r. |
Thymus |
X |
N.t.r. |
Trachea |
X |
N.t.r. |
Lungs |
X |
N.t.r. |
Heart |
X |
N.t.r. |
Kidneys |
X |
N.t.r. |
Urinary Bladder |
X |
N.t.r. |
Ovaries |
X |
N.t.r. |
Uterus |
X |
N.t.r. |
Treatment Area |
- |
- |
Adrenals |
X |
N.t.r. |
Pancreas |
X |
N.t.r. |
Particulars: none |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: not classified
DSD: not classified
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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