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Diss Factsheets
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EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Ethyl trifluoroacetate (TFAE) is a colourless fluid liquid, transparent, with characteristic pleasant odour (purity >=99%), considered to be highly volatile.
By oral route, TFAE may be hydrolysed into ethanol and TFA which is fully miscible in water, where TFA will exist under its ionised form (acetate). Afterwards, TFA dissolved in acidic gastric liquid may be submitted to enteropatic circulation, then distributed in the body via the blood as ionised form considering its distribution coefficient log D (-0.58) and finally excreted mainly in the urine and in the bile (less extent) as parent compound. In other way, considering the acidity of the gastric fluid (i.e. pH =1), it is unlikely that the hydrolysis of TFAE may occur quickly after ingestion. Therefore, in the meantime, TFAE may be systemic absorbed after metabolism in the liver, and then excreted as parent compound or as conjugated metabolites.
Absorption of TFAE may occur after skin contact even if this absorption may be very limited considering the absence of local and systemic effects in the acute dermal toxicity study up to 2011 mg/kg bw and higher, the absence of skin irritation and sensitisation by skin contact.
In any case, if TFAE is dermal absorbed , it may be distributed in the body via the blood where it is likely hydrolised into ethanol and ionised form TFA and finally excreted mainly in the urine and in the bile (less extent) as parent compound.
Considered as highly volatile based on a read-across approach with TFA and TFAH (see 4.6), TFAE vapor may be inhaled at room temperature and then absorbed as such or as TFA and ethanol after hydrolysis of vapour TFAE in the mucus.Then, TFA is distributed in the body via the blood as ionised form considering its distribution coefficient log D (-0.58) and finally excreted mainly in the urine and in the bile (less extent) as TFA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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