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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1962
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable publication which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
Range-Finding Toxicity Data: List VI
Author:
Smyth HF, Carpenter CP, Weil CS et al.
Year:
1962
Bibliographic source:
Am Ind Hyg Assoc J 23: 95-107

Materials and methods

Principles of method if other than guideline:
Method: other: Smyth/Carpenter
GLP compliance:
no
Remarks:
prior to GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-ethynylcyclohexanol
EC Number:
201-100-9
EC Name:
1-ethynylcyclohexanol
Cas Number:
78-27-3
Molecular formula:
C8H12O
IUPAC Name:
1-ethynylcyclohexanol
Test material form:
not specified

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 2.5 - 3.5 kg

Administration / exposure

Type of coverage:
occlusive
Vehicle:
not specified
Details on dermal exposure:
Penetration of rabbit skin was estimated by the one-day cuff method of Draize and associates. The fur was closely clipped over the entire trunk, and the dose retained beneath an impervious plastic film.
Duration of exposure:
24 hours
Doses:
up to 20 mL/kg bw
No. of animals per sex per dose:
4 animals
Control animals:
not specified
Details on study design:
After 24 hours contact the film was removed. Mortality was considered complete after 14 additional days.
- Duration of observation period following administration: 14 days
Statistics:
The most probable LD50 was estimated by the methods of Thompson (1947) and Weil (1952).

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
1 000 mg/kg bw
Remarks on result:
other: reported as 1.00 mL/kg bw
Sex:
male
Dose descriptor:
LD50
Effect level:
>= 0.68 - <= 1.48 mL/kg bw
Mortality:
Death occurred within 14 days, no detailed information provided.
Clinical signs:
other: No information provided
Gross pathology:
No information provided

Any other information on results incl. tables

24 h exposure time, deaths within 14 days. Limits of +/- 1.96 standard deviation using the method of Thompson: 680 - 1480 mg/kg bw. Original LD50 given as 1.0 mL/kg bw.

Applicant's summary and conclusion