Propanoic acid, 2-[4-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenoxy]-, (2R)-

Developmental toxicity / teratogenicity

Administrative data

Endpoint:

developmental toxicity

Type of information:

experimental study

Adequacy of study:

supporting study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Only very little information is available. The information is based on an internal memorandum with a short summary of the results of a study report. The full study report is not available.

Data source

Reference

Reference Type:

other company data

Title:

Unnamed

Year:

1981

Materials and methods

GLP compliance:

not specified

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

(RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic

EC Number:

614-949-9

Cas Number:

69335-91-7

Molecular formula:

C15H12F3NO4

IUPAC Name:

(RS)-2-[4-(5-Trifluoromethyl-2-pyridyloxy)phenoxy]propionic

Constituent 2

Reference substance name:

2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid

IUPAC Name:

2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid

Details on test material:

The test substance is the racemate 2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 69335-91-7). It is a 1:1 mixture of the two enantiomers (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 83066-88-0; the substance defined in section 1) and (2S)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid (CAS# 95977-30-3).

Test animals

Species:

rat

Strain:

not specified

Administration / exposure

Route of administration:

oral: unspecified

Vehicle:

not specified

Analytical verification of doses or concentrations:

not specified

Results and discussion

Results: maternal animals

Maternal developmental toxicity

Details on maternal toxic effects:

Maternal toxic effects:no effects

Results (fetuses)

Details on embryotoxic / teratogenic effects:

Embryotoxic / teratogenic effects:no effects

Fetal abnormalities

Abnormalities:

not specified

Overall developmental toxicity

Developmental effects observed:

not specified

Any other information on results incl. tables

Full information as given in the memorandum:

Oral administration of 0.4, 2.0, 10.0, 25.0 and 50.0 mg/kg/day to pregnant rats from 7 days to day 17 of gestation produced no maternal or foetal effects in a preliminary teratogenicity study.

Remark: In the internal memorandum the dose levels were given as "0.4, 2.0, 10.0, 25.0 and 50.0 mg/g/day". It is assumed that this is due to a typing error and "mg/g/day" should read as "mg/kg/day". All dose levels refer to the test substance (i.e. the racemate).