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Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2010
Report date:
2010

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
no
Remarks:
The study was conducted according to guideline in effect at time of study conduct.
Qualifier:
according to guideline
Guideline:
EPA OPPTS 870.2400 (Acute Eye Irritation)
Deviations:
no
Remarks:
The study was conducted according to guideline in effect at time of study conduct.
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
EC Number:
248-576-4
EC Name:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctanesulphonyl chloride
Cas Number:
27619-89-2
Molecular formula:
C8H4ClF13O2S
IUPAC Name:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctane-1-sulfonyl chloride
Details on test material:
-Purity: > 98.0%

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: The left eye of each rabbit remained untreated with the test substance and served as a control.
Duration of treatment / exposure:
Single exposure
Observation period (in vivo):
Approximately 1, 24, 48, and 72 hours following administration
Number of animals or in vitro replicates:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
conjunctivae score
Basis:
other: range
Time point:
other: 1 to 72 hours
Score:
0 - 2
Max. score:
3
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
cornea opacity score
Basis:
other: range
Time point:
other: 1 to 72 hours
Score:
0
Max. score:
2
Irritation parameter:
iris score
Basis:
other: range
Time point:
other: 1 to 72 hours
Score:
0 - 1
Max. score:
2
Reversibility:
fully reversible within: 24 hours
Irritation parameter:
chemosis score
Basis:
other: range
Time point:
other: 1 to 72 hours
Score:
0 - 1
Max. score:
4
Reversibility:
fully reversible within: 48 hours

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification
Remarks:
Migrated information
Conclusions:
Conjuctival redness (score of 1 or 2), chemosis (score of 1), discharge (score of 1 or 2), and /or iritis (score of 1) were observed during the study.
Executive summary:

The test substance was evaluated for acute eye irritation potential in 3 young adultwhite rabbits. An aliquot of 0.1 g of the test substance was administered to 1 eye of each animal. The eyes remained unwashed following treatment. The untreated eye served as a control. The conjunctiva, iris, and cornea of each treated eye were evaluated and scored according to a numerical scale approximately 1, 24, 48, and 72 hours, following administration. There was no corneal opacity observed in any treated eye during the study. Iritis (score of 1), conjunctival redness (score of 1 or 2), conjunctival chemosis (score of 1), and discharge (score of 1 or 2) were observed in the treated eye of all three rabbits. All ocular irritation reversed by 72 hours.