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EC number: 916-241-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 14, 1990 - November 28, 1990
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reliability 2 is assigned because the study is conducted according to OECD TG 401, without deviations that influence the quality of the results but predating GLP requirements
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- (1987)
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Reaction mass of 6-(butan-2-yl)quinolone and 8-(butan-2-yl)quinoline
- EC Number:
- 916-241-8
- Molecular formula:
- C13H15N
- IUPAC Name:
- Reaction mass of 6-(butan-2-yl)quinolone and 8-(butan-2-yl)quinoline
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): Isobutylquinoleine D 49560
- Chemical name: Quinoleine, 6-(1-methylpropyl) (main constituent) Quinoleine, 8-(1-methylpropyl) (11-15%)
- Physical state: liquid
- Storage condition of test material: At room temperature (about 20°C); protected from light
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Fü-Albino outbred stock Ibm:RORO (SPF)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Biological Research Laboratories (BRL), CH-4414 Füllinsdorf, Switzerland
- Age at study initiation: No data
- Weight at study initiation: males: 116.0 - 128.0 g; females: 116.0 - 121.9 g
- Fasting period before study: overnight before treatment till 4 hours after treatment
- Housing: group housing 3 animals per cage in macrolon cages type III
- Diet: free access to KLIBA 25-343 (batch 76/90), complete rodent maintenance diet
- Water: free access to tap water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2
- Humidity (%): 55 +/- 10
- Air changes (per hr): 15 - 20 cycles
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- arachis oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 250, 320 and 400 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 5 mL/kg
CLASS METHOD
- Rationale for the selection of the starting dose: from a pilot study with the substance it was concluded that the LD50 could be near or above 2000 mg/kg. - Doses:
- 0, 1250, 1600 and 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: The animals were observed 30 minutes, 1, 2 and 4 hours after application and thereafter daily
- Necropsy of survivors performed: yes, at the end of the observation period the animals were killed by CO2 asphyxia, necropsied and subjected to examination for gross pathological changes.
- Body weights: Individual body weights were recorded immediately before treatment and then on the 7th and 14th day of the observation period. - Statistics:
- Not performed.
Results and discussion
- Preliminary study:
- From a pilot study with the substance it was concluded that the LD50 could be near or above 2000 mg/kg.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths were observed.
- Clinical signs:
- other: At the dose level of 1250 mg/kg, the males showed moderate to trace sedation during the first 2 hours after treatment, whereas the females remained without symptoms. In general, the observed symptoms were mild and dissappeared completely within 4 hours af
- Gross pathology:
- No signs of gross pathological changes were found necropsy, exept in one male in the 2000 mg/kg dose group, where the stomach was partially grown together with rate and liver tissue.
Any other information on results incl. tables
The effect seen in the stomach of the one male may be indicative for irritation of the test substance.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study with male and female rats, performed according to OECD 401 test guidelines, an LD50 >2000 mg/kg bw was determined.
- Executive summary:
Sec Butyl Quinoline was tested in an acute oral toxicity study with male and female rats, performed according to the OECD 401 guideline. At the dose level of 1250 mg/kg, the males showed moderate to trace sedation during the first 2 hours after treatment, whereas the females remained without symptoms. In general, the observed symptoms were mild and dissappeared completely within 4 hours after treatment, exept in one male and one female in the 1600 mg/kg dose group, which still showed symptoms like gasping and/or sedation 24 hours after tretament. No signs of gross pathological changes were found necropsy, exept in one male in the 2000 mg/kg dose group, where the stomach was partially grown together with rate and liver tissue, which may indicate some irritation of the substance. The LD50 was established to be >2000 mg/kg bodyweight.
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