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EC number: 291-378-8 | CAS number: 90388-00-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation: EU: R38 (irritating); CLP: not irritating (BASF, 2007)
Eye irritation: EU: not irritating, CLP: not irritating (BASF, 2007)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin irritation:
The primary skin irritation potential of Heptadecanol N was investigated according to OECD test guideline no. 404 (BASF, 2007). The test item was applied by topical semi-occlusive application of 0.5 mL to the intact left flank of each of three young adult New Zealand White rabbits. The duration of treatment was four hours. The scoring of skin reactions was performed 1, 24, 48 and 72 hours, as weil as 7, 10 and 14 days after removal of the dressing. The mean score was calculated across 3 scoring times (24, 48 and 72 hours after patch removal) for each animal for erythemaleschar grades and for oedema grades, separately. The mean erythemaleschar score was 2.00 for each of the three animals and the mean oedema score was 1.00 for each of the three animals. The application of Heptadecanol N to the skin resulted in mild to moderate signs of irritation including erythema, oedema and scaling. At the end of the two week observation period, very slight erythema and scaling were still present in two animals, respectively. The test item caused no staining of the treated skin. No corrosive effects were noted on the treated skin of any animal at any of the measuring intervals and no clinical signs were observed. At the end of the two-week observation period, very slight erythema or scaling was still present in one animal, respectively. Thus, the test item induced moderate skin irritation which was not fully reversible during the observation period.
Eye irritation:
The primary eye irritation potential of Heptadecanol N was investigated according to OECD
test guideline no. 405 (BASF, 2007). The test item was applied by instillation of 0.1 mL into the left eye of
each of three young adult New Zealand White rabbits. Scoring of irritation effects was
performed approximately 1, 24, 48 and 72 hours after test item instillation.
The mean Score was calculated across 3 scoring times (24, 48 and 72 hours after instillation)
for each animal for corneal opacity, iris, redness and chemosis of the conjunctivae,
separately. The individual mean scores for corneal opacity and iris were 0.00 for all three
animals. The individual mean scores for the conjunctivae were 0.00, 0.33 and 0.33 for
reddening, respectively, and 0.00 for chemosis for each of the three animals.
The instillation of Heptadecanol N into the eye resulted in mild, early-onset and transient
ocular changes, such as reddening of the conjunctivae and sclerae, and chemosis. These
effects were reversible and were no longer evident 48 hours after treatment. No abnormal
findings were observed in the Cornea or iris of any animal at any of the examinations. No
corrosion was observed at any of the measuring intervals. No staining of the treated eyes by
the test item was observed and no clinical signs were observed.
Thus, the test item did not induce significant or irreversible damage to the rabbit eye.
Justification for classification or non-classification
The test item showed some irritation to the skin but not to the eye. The skin irritation leads to an R38 classification according to EU Directive 67/548/EC but there is no need to classify for skin irritation according to the CLP Regulation 1272/2008/EC.
Based on the observed effects on the rabbit eye, there is no need for classification according to the EU Directive 67/548/EC and according to the CLP Regulation 1272/2008/EC.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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