Amines, C14-16 (even numbered)-alkyldimethyl, N-oxides

Density

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

relative density

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

21/07/2010 - 22/07/2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: This study was performed to the required guideline under GLP. Results from the water solubility study suggest that some degradation of the substance may have taken place during drying.

Justification for type of information:

1. HYPOTHESIS FOR THE CATEGORY APPROACH (ENDPOINT LEVEL)
Please refer to the Amine Oxide Category justification attached in Section 13

2. CATEGORY APPROACH JUSTIFICATION (ENDPOINT LEVEL
Please refer to the Amine Oxide Category justification attached in Section 13

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

yes

Remarks:

density was measured at 23 °C rather than 20 °C

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Type:

relative density

Density:

0.716

Temp.:

23 °C

The density of the substance is reported as 716 kg/m3. This was converted into relative density by dividing by the density of water at 4 °C (999.9720 kg/m3). The density measurement was performed at 23 °C rather than 20 °C as specified in the test guideline, however because the substance is a solid with melting point > 100 °C it is not anticipated that this will affect the result.

Executive summary:

The relative density of C12 -14 AO was determined in a test conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A3 under GLP. The measured density of the substance, 716 kg/m3 at 23 °C, was divided by the relative density of water at 4 °C to derive the relative density of 0.716.

Reference 2

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

27-10-2014 - 28-11-2014

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

Not GLP

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

yes

Remarks:

vacuum not applied

GLP compliance:

no

Type of method:

pycnometer method

Type:

relative density

Density:

0.983

Temp.:

23 °C

The density of the substance is reported as 0.983 g/cm3, equivalent to 983 kg/m3. This was converted into relative density by dividing by the density of water at 4 °C (999.9720 kg/m3).

Conclusions:

The relative density of the substance is 0.983.

Executive summary:

The relative density of C12 AO is 0.983 based on the results of a study performed according to OECD TG 109 (pycnometer method).

Description of key information

The relative density of the substance is approximately 0.716, based on data from the C12-14 AO analogue.

Key value for chemical safety assessment

Relative density at 20C:

0.716

Additional information

The relative density of C14-16 AO has not been measured directly as experience with other amine oxides has shown that it is not possible to produce a stable and/or water-free sample of these substances by freeze-drying.

Measured data are available for the C12 -14 amine oxide from a test conducted in accordance with the procedure described in EU Regulation (EC) 440/2008, Annex Part A test A3 under GLP [Younis S (2010)]. The measured density of the substance, 716 kg/m3 at 23 °C, was divided by the relative density of water at 4 °C to derive the relative density of 0.716.

The result of this study is supported by a study performed using C12 AO, conducted according to OECD TG 109 (pycnometer method) [ Calvo X (2014)] in which a value for relative density of 0.983 was derived.