Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and suitable for read-across.

Data source

Reference
Reference Type:
publication
Title:
Titanium tetrachloride burns to the eye
Author:
Chitkara DK, McNeela BJ
Year:
1992
Bibliographic source:
British Journal of Ophthalmology 76: 380-382

Materials and methods

Study type:
clinical case study
Endpoint addressed:
eye irritation
Principles of method if other than guideline:
Eight cases of chemical burns of the eyes from titanium tetrachloride are presented.
GLP compliance:
no
Remarks:
not applicable

Test material

Constituent 1
Reference substance name:
7750-45-0
Cas Number:
7750-45-0
IUPAC Name:
7750-45-0
Details on test material:
- Name of test material (as cited in study report): Titanium tetrachloride

Method

Type of population:
occupational
Subjects:
- Number of subjects exposed: 8
- Sex: All male
- Age: 19 - 46 years old
- Race: unknown
Ethical approval:
not applicable
Route of exposure:
ocular
Reason of exposure:
accidental
Details on exposure:
All eight patients were accidentally exposed to titanium tetrachloride splashes. The exposure occured on various parts of the body, mainly face, eyes, and skin.

Results and discussion

Clinical signs:
The severity of the clinical signs was dependent on the exposure. The following observations were made on some of the workers: Hypopyon, glaucoma, entropion, trichiasis, corneal scarring and vascularisation, enucleation, cataracis, corneal perforation, corneal neovascularisation, symblepharon, pseudoterygium, and pulmonary oedema.

Applicant's summary and conclusion