Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Some information in this page has been claimed confidential.

Administrative data

Endpoint:
genetic toxicity in vitro
Remarks:
Type of genotoxicity: other: calculation
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Validated QSAR System - Substance is in domain of the system

Data source

Reference
Reference Type:
other: QSAR
Title:
Unnamed
Year:
2009
Report date:
2009

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
A quantitative structure-activity relationship (QSAR) system for the estimation of the mutagenic potency in S. typhimurium that incorporates S9 metabolism and consideres the potential of parent chemicals and/or their activated metabolites to react with DNA. A chemically divers training set was used for which Ames mutagenicity data is available.
GLP compliance:
no
Type of assay:
other: Calculation

Test material

Reference
Name:
Unnamed
Type:
Constituent

Results and discussion

Any other information on results incl. tables

The QSAR program calculated a negative mutagenic potential of the test substance in bacteria.

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Applicant's summary and conclusion