1,1,2,3,3-pentamethylindan

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1981

Report date:

1981

Materials and methods

Test guideline

Qualifier:

no guideline available

Guideline:

other: Lab SOP PH-402 followed

Deviations:

not specified

Principles of method if other than guideline:

Followed Test Facility SOP No. PH-402. Study in compliance with the Good Laboratory Practice Regulations.

GLP compliance:

yes

Test type:

fixed dose procedure

Test material

Test material information

Constituent 1

Reference substance name:

1,1,2,3,3-pentamethylindan

EC Number:

214-868-5

EC Name:

1,1,2,3,3-pentamethylindan

Cas Number:

1203-17-4

Molecular formula:

C14H20

IUPAC Name:

1,1,2,3,3-pentamethyl-2,3-dihydro-1H-indene

Details on test material:

Noted in study as Compound 81-205-01

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

4300, 4500, 4700 & 5000 mg/kg

No. of animals per sex per dose:

10 animals per dose. 5 males and 5 females. 5 animals per sex per dose.

Control animals:

not specified

Results and discussion

Preliminary study:

Three groups of four rats per group (2 males and 2 females) were orally administered at 5000, 1600 and 500 mg/kg

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

4 500 mg/kg bw

Based on:

test mat.

95% CL:

4 286 - 4 725

Applicant's summary and conclusion

Conclusions:

The calculated acute oral LD50 in male and female rats is 4500 mg/kg.

Executive summary:

The calculated acute oral LD50 in male and female rats is 4500 mg/kg.