1,3-diisopropylbenzene

Eye irritation

Administrative data

Endpoint:

eye irritation, other

Remarks:

in vivo study that was performed prior to current requirement for in vitro alternative testing

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: older study; not conducted in accordance with current GLP guidelines

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1984

Report date:

1984

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 405 (Acute Eye Irritation / Corrosion)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

1,4-diisopropylbenzene

EC Number:

202-826-9

EC Name:

1,4-diisopropylbenzene

Cas Number:

100-18-5

Molecular formula:

C12H18

IUPAC Name:

1,4-di(propan-2-yl)benzene

Constituent 2

Reference substance name:

p-diisopropylbenzene

IUPAC Name:

p-diisopropylbenzene

Test animals / tissue source

Species:

rabbit

Strain:

New Zealand White

Test system

Vehicle:

unchanged (no vehicle)

Controls:

no

Duration of treatment / exposure:

24 hours

Observation period (in vivo):

24 hours

Number of animals or in vitro replicates:

3

Details on study design:

Eye irritation studies in the Kodak laboratory were conducted using a method similar to that described in the current OECD Guideline. However, the test material was administered to six, rather than three, rabbit eyes. Three of the eyes were subsequently washed, so the effect of washing on the subsequent development of irritant responses could be evaluated. The effect of washing is not evaluated in current Guideline studies.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Time point:

other: 24 hours

Score:

0

Max. score:

4

Reversibility:

fully reversible

Irritant / corrosive response data:

Irritation, limited to erythema of the adnexa, resolved after one hour. No adnexal or corneal staining was observed. Immediate washing was beneficial.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Based upon the findings of this study, p-diisopropylbenzene is slightly irritating to the eyes of rabbits.

Executive summary:

A 0.1 mL aliquot of p-diisopropylbenzene was instilled into both eyes of 3 rabbits; in one eye of each rabbit, the material was immediately rinsed with water, while in the other eye, the material remained without washing. Immediately after instillation, slight erythema was observed in 3 of 3 rabbits that was limited to the adnexa, and washing was palliative. At one hour after instillation, all signs of irritation had resolved in all rabbits.