1,3-diisopropylbenzene

Endpoint summary

Description of key information

Acute toxicity – oral/ rats
Slightly toxic in oral route. LD50 > 5000 mg/kg body weight.

 

Acute toxicity – inhalation
Not considered to be a relevant route of potential human exposure

Acute toxicity – dermal/ guinea pigs

Slightly toxic by the dermal route, LD50 > 20 mL/kg bw/d (= ca. 20000 mg/kg bw/d).

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 JUL 1985 - 20 DEC 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test was conducted according to an internal method. The test SOP NO. TA 300 and TA 120 are mentioned. The method of calculation was the Weil Method.

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

no

Specific details on test material used for the study:

TEST MATERIAL
- name as cited in test report: m-diisopropylbenzene
- Molecular weight: 162 g/mol
- Molecular formula: C12H18
- Physical state: liquid

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: not specified
- Stability with H+; OH-; Heat, Light, H2: given

Species:

rat

Strain:

Crj: CD(SD)

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Strain: CRL: CD (SD) BR
- Weight at study initiation:
Male: 136 - 149g,
Female: 143 - 160g

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Remarks:

undilute as received)

Details on oral exposure:

Test article was administered neat via oral gavage

Doses:

1250, 2500, 5000 mg/kg bw

No. of animals per sex per dose:

five (5)

Control animals:

not specified

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Based on:

test mat.

Mortality:

No deaths were reported for neither low, mid nor high dose group animals.

Gross pathology:

No compound-related effects were observed at gross pathology examination of the high-dose group of animals.

"At most, slightly toxic orally. No compound-related effects were observed at gross pathlogy examination of the high-dose group of animals."

LD50 (males) > 5000 mg/kg

LD50 (females) > 5000 mg/kg

Interpretation of results:

GHS criteria not met

Conclusions:

No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound was considered to be slightly toxic following oral administration. The LD50 value was greater than 5000 mg/kg body weight.

Executive summary:

The acute toxicity to rats in oral gavage test was performed. No compound-related effects were observed at gross pathology examination of the high-dose group of animals. The compound was considered to be - at most - slightly toxic following oral administration. The LD50 value was greater than 5000 mg/kg body weight.

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 JUL 1985 - 20 DEC 1985

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

no guideline followed

Principles of method if other than guideline:

The test was conducted according to an internal method. The following is mentioned: Test SOP No. TA 310, TA 160 and TA 120

GLP compliance:

not specified

Test type:

standard acute method

Limit test:

yes

Species:

guinea pig

Strain:

Hartley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Strain: CRL (HA)BR Hartley
- Weight at study initiation:
Male: 390 - 483g,
Female: 282 - 349g

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Remarks:

undilute as received

Duration of exposure:

2 weeks

Doses:

20 mL/kg

No. of animals per sex per dose:

five (5)

Control animals:

no

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 20 mL/kg bw

Based on:

test mat.

Clinical signs:

other: no evidence of percutaneous absorption

Interpretation of results:

GHS criteria not met

Conclusions:

At most, test item is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20 mL/kg bw (= ca. 20000 mg/kg bw/d).

Executive summary:

The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route. There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20mL/kg bw (= ca. 20000 mg/kg bw/d).

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

> 20 000 mg/kg bw

Additional information

Acute toxicity – oral
The acute toxicity of m-DIPB to rats in oral gavage test was performed. No compound-related effects were observed at gross pathology examination of the high-dose group of animals.

The compound was considered to be slightly toxic following oral administration. The LD50 value was greater than 5000 mg/kg body weight.

 

Acute toxicity – inhalation
Inhalation is not considered to be a relevant route of potential human exposure

Acute toxicity – dermal
The acute toxicity to guinea pig in dermal test was performed. At most, test item is only slightly toxic by the dermal route.

There was no evidence of percutaneous absorption. LD50 value was determined to be greater than 20mL/kg bw (= ca. 20000 mg/kg bw/d).

Justification for classification or non-classification

Based on the available data, test item is not classified for acute toxicity according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No 1272/2008 and UN Globally Harmonized System of Classification and Labelling of Chemicals (GHS).