Registration Dossier

Administrative data

Description of key information

Skin irritation: In a rabbit skin irritation/corrosion test according to OECD Guideline 404, Jeffamine RFD 270 showed corrosive effects towards the skin (Lemoncelli, 2012).
Eye irritation: No study on eye irritation/corrosion is available. However, in accordance with the specific rules for adaptation from column 1 (REACH Annex VII and VIII), no in vitro or in vivo eye irritation study needs to be conducted as the criteria are met for classification of the substance as corrosive to the skin.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation / corrosion

Lemoncelli (2012) studied skin irritation/corrosion by applying Jeffamine RFD 270 on three test sites on the back of a single animal. The test article was applied to one site (~ 5 cm x 5 cm) on the dorsal trunk of one animal (intact sites) in semi-occlusive condition, according to OECD guideline 404 and EPA OPPTS 870.2500. Dermal observations were performed as follows: 3 minutes and 60 minutes sites: the animal was examined for signs of erythema and edema and the responses scored immediately after patch removal and at 30-60 minutes, then daily as needed; 4 hour sites, if applicable: The animal was examined for signs of erythema and edema and the responses scored 30-60 minutes, 24, 48, 72 hours (± 1 hour) after patch removal, and additionally as needed, daily. Since irritation persisted at the 72 hour scoring interval, daily scoring occurred for a maximum of 14 days. Lesions were scored according to the Draize system: erythema and edema scores of 4 were observed. Effects were not fully reversible within 14 days. Following responses were observed: 3 minutes exposure: severe erythema and severe edema (starting on day 8), necrosis of the skin (starting on day 8 through to day 10); 60 minutes exposure: severe erythema and edema (starting on day 2), necrosis of the skin (starting on day 2 through to day 14); 4 hour exposure: severe erythema and severe edema (starting at 30-60 minutes after unwrap), necrosis of the skin (starting on day 1 through to day 14). In conclusion, the substance was found to be corrosive according to the criteria of the CLP Regulation.

Eye irritation:

In accordance with the specific rules for adaptation from column 1 (REACH Annex VII and VIII), no in vitro or in vivo eye irritation study needs to be conducted as the criteria are met for classification of the substance as corrosive to the skin.


Justification for selection of skin irritation / corrosion endpoint:
Only one reliable study available

Effects on skin irritation/corrosion: corrosive

Justification for classification or non-classification

Based on the available data and the criteria of the DSD Regulation, Jeffamine RFD 270 is classified as R34 and R41. According to the criteria of the CLP Regulation the substance is classified as corrosive category 1C, H314 (causes severe skin burns and eye damage). As the substance is corrosive to the skin, it should also be classified for serious eye damage category 1, H318 (causes serious eye damage).