Reaction products of 1,4-cyclohexanedimethanol with propylene oxide and ammonia

Endpoint summary

Description of key information

Three short term studies performed with the test substance were available. The acute toxicity study of Rainbow trout (Parr, 2012) resulted in an LC50 of 75 mg/L. The toxicity of the test substance towards Daphnia magna (Goodband and Mullee, 2012) resulted in an LC50 of 7.5 mg/L, whereas the highest ecotoxicity was observed for algae (Vrijenhoef, 2012), which resulted in an ErC50 of 0.16 mg/L. Therefore, the test substance can be considered to be very toxic to aquatic algae.

Additionally, a chronic toxicity study was also conducted on Daphnia Magna (Kucherka, 2017). Exposure of Daphnia magna to the test item resulted in significant mortalities at the concentrations of 10 and 20 mg/L resulting in 60% and 100% mortalities by Days 19 and 6, respectively. The 21-Day EC50(immobilization) value, based on nominal concentrations, for the parental daphnia generation (P1) was calculated to be 9.8 mg/L. The "Lowest Observed Effect Concentration" (LOEC) and the "No Observed Effect Concentration" (NOEC) for immobilization based on nominal concentrations were 10 and 5.0 mg/L, respectively.

No significant impairment of reproduction was observed at the 0.625, 1.25, 2.5, 5.0 and 10 mg/L test concentrations during the test. The 21-Day EC50(reproduction) based on nominal concentrations was 10 mg/L. The "Lowest Observed Effect Concentration" (LOEC) and the "No Observed Effect Concentration" (NOEC) for reproduction based on nominal concentrations were 20 and 10 mg/L, respectively.

Finally, in a 3 -h respiration inhibition study (Best, 2014) conducted according to OECD guideline 209 the LC50 ranged between 100 -1000 mg/L, based on these results it was considered that no definitive test should be conducted.