Registration Dossier
Registration Dossier
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EC number: 255-460-7 | CAS number: 41611-76-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Five male and five female Wister rats (average weight at the beginning of the study 197 and 174 g, respectively ) received per gavage a single dose of 5000 mg/kg bw Macrolex Blau CA 51056. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed on animals killed after the observation period.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone
- EC Number:
- 255-460-7
- EC Name:
- 1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone
- Cas Number:
- 41611-76-1
- Molecular formula:
- C32H30N2O2
- IUPAC Name:
- 1,4-bis[(2-ethyl-6-methylphenyl)amino]-9,10-dihydroanthracene-9,10-dione
- Details on test material:
- Macrolex Blau CA 51056 = CAS 41611-76-1
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Doses:
- 5000 mg/kg bw (m + f)
- No. of animals per sex per dose:
- 5 male and five female animals per dose
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Clinical signs:
- other: other:
Any other information on results incl. tables
A dose of 5000 mg/kg bw was tolerated without symptoms.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
Five male and five female Wistar rats (average weight at the beginning of the study 197 and 174 g, respectively ) received per gavage a single dose of 5000 mg/kg bw Macrolex Blau CA 51056. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed on animals killed after the observation period.
A dose of 5000 mg/kg bw was tolerated without symptoms. The LD50 is > 5000 mg/kg bw for male and female rats.
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