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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1986
Report date:
1986

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Principles of method if other than guideline:
Five male and five female Wister rats (average weight at the beginning of the study 197 and 174 g, respectively ) received per gavage a single dose of 5000 mg/kg bw Macrolex Blau CA 51056. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed on animals killed after the observation period.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone
EC Number:
255-460-7
EC Name:
1,4-bis[(2-ethyl-6-methylphenyl)amino]anthraquinone
Cas Number:
41611-76-1
Molecular formula:
C32H30N2O2
IUPAC Name:
1,4-bis[(2-ethyl-6-methylphenyl)amino]-9,10-dihydroanthracene-9,10-dione
Details on test material:
Macrolex Blau CA 51056 = CAS 41611-76-1

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
polyethylene glycol
Doses:
5000 mg/kg bw (m + f)
No. of animals per sex per dose:
5 male and five female animals per dose
Control animals:
no

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
>= 5 000 mg/kg bw
Based on:
test mat.
Clinical signs:
other: other:

Any other information on results incl. tables

A dose of 5000 mg/kg bw was tolerated without symptoms.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Executive summary:

Five male and five female Wistar rats (average weight at the beginning of the study 197 and 174 g, respectively ) received per gavage a single dose of 5000 mg/kg bw Macrolex Blau CA 51056. The animals were observed for mortality, weight and clinical signs through day 14. A gross necropsy was performed on animals killed after the observation period.


A dose of 5000 mg/kg bw was tolerated without symptoms. The LD50 is > 5000 mg/kg bw for male and female rats.