Registration Dossier
Registration Dossier
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EC number: 208-488-9 | CAS number: 530-62-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- other: data from hydrolysed substance
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- substance 530-62-1 hydrolyses
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Imidazole
- EC Number:
- 206-019-2
- EC Name:
- Imidazole
- Cas Number:
- 288-32-4
- Molecular formula:
- C3H4N2
- IUPAC Name:
- 1H-imidazole
- Test material form:
- other: 99%
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- water
- Controls:
- not specified
- Amount / concentration applied:
- 100mg
- Duration of treatment / exposure:
- 14d
- Observation period (in vivo):
- 14d
- Number of animals or in vitro replicates:
- 3 rabbits
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 3
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 14 d
- Score:
- 2
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Conclusions:
- MMAS (Modified Maximum Average Score) of imidazole: 59.3
Imidazole was irritant based on cornea opacity grade 3 and grade 2 effects on iris in one animal after 14 days.
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