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Diss Factsheets
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EC number: 230-813-8 | CAS number: 7328-22-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Remarks:
- QSAR model based on several hundred chemicals tested in the same human skin model at the Central Toxicology laboratory and dermal Technology Laboratory .
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
- Principles of method if other than guideline:
- In silico prediction of skin permeation (human skin)
Test material
- Reference substance name:
- 2-(2-butoxyethoxy)ethyl methacrylate
- EC Number:
- 230-813-8
- EC Name:
- 2-(2-butoxyethoxy)ethyl methacrylate
- Cas Number:
- 7328-22-5
- Molecular formula:
- C12H22O4
- IUPAC Name:
- 2-(2-butoxyethoxy)ethyl 2-methylprop-2-enoate
- Test material form:
- liquid
Constituent 1
Results and discussion
- Absorption in different matrices:
- The absorption rate of Butyldiglycol methacrylate through human skin was predicted to be 24.992 µg/cm²/h (moderate absorption)
Any other information on results incl. tables
In silico prediction of dermal absorption of higher methacrylates
In a QSAR model based on the physico-chemical properties (MW, logPow and satutared aqueous solubility) of chemicals the permeability of dermal absorption of a group of higher methacrylates was calculated. QSARs, when applied to estimating dermal permeability coefficients are also known as quantitative structure-permeability relationships (QSPeRs or QSPRs). The prediction model used in this investigation for a set of 54 methacrylate chemicals was based on an established model [Potts and Guy, (1992). Predicting Skin Permeability, Pharm. Res. 9(5): 663-669], using data derived with human epidermal membranes. The QSPeR approach can be used to identify compounds that are more likely to cross the stratum corneum barrier. Well dermal absorbed compounds include a low molecular weight, a general tendency towards being lipophilic in order to partition into the lipid rich stratum corneum/epidermis, but having sufficient aqueous solubility to cross the more polar regions of the dermis, prior to resorption into the blood circulation.
The dermal absorption was expressed using the permeability coefficient Kp which characterises the steady-state permeation rate of a chemical from a specific vehicle through a given membrane.
Terms used for categorising absorption of chemicals through human skin
Kp (cm/h) |
Absorption Rate (µg/cm²/h) |
Relative Absorption Rate Category |
Predicted Absorption fromExposure |
1 x 10-2– 10-1 |
> 500 |
Fast |
very high |
1 x 10-3– 10-2 |
100-500 |
rapid –fast |
high |
1 x 10-4– 10-3 |
10-50 50-100 |
slow – moderate moderate – rapid |
moderate |
1 x 10-5– 10-4 |
0.1-10 |
very slow – slow |
low |
1 x 10-6– 10-5 |
0.001-0.1 |
extremely – very slow |
minimal |
< 1 x 10-6 |
< 0.001 |
extremely slow |
negligible |
The absorption rate of Butyldiglycol methacrylate was predicted to be 24.992 µg/cm²/h. Therefore the dermal absorption is predicted to be moderate.
Applicant's summary and conclusion
- Conclusions:
- In a QSAR model based on the physico-chemical properties (MW, logPow and satutared aqueous solubility) of chemicals the permeability of dermal absorption of a group of higher methacrylates was calculated. The absorption rate of Butyldiglycol methacrylate through human skin was predicted to be 24.992 µg/cm²/h. Therefore the dermal absorption is predicted to be moderate.
- Executive summary:
In a QSAR model based on the physico-chemical properties (MW, logPow and satutared aqueous solubility) of chemicals the permeability of dermal absorption of a group of higher methacrylates was calculated.
The dermal absorption was expressed using the permeability coefficient Kp which characterises the steady-state permeation rate of a chemical from a specific vehicle through a given membrane.
The absorption rate of Butyldiglycol methacrylate was predicted to be 24.992 µg/cm²/h. Therefore the dermal absorption is predicted to be moderate.
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