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EC number: 209-750-5 | CAS number: 592-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound butyl chloroformate (CAS 592-34-7, rapidly hydrolyzing): No data available.
Hydrolysis product hydrogen chloride (HCL, CAS 7647 -01 -0): Acutely very toxic to algae (pH dependent).
Hydrolysis product butanol (CAS 71 -36 -3): With high probability acutely not harmful to algae.
Key value for chemical safety assessment
Additional information
Data for parent compound butyl chloroformate (CAS 592-34-7):
No data on the algal toxicity are available for butyl chloroformate (CAS 592-34-7).
However, as the substance rapidly hydrolyses in contact with water to butanol (CAS 71 -36 -3), hydrogen chloride (CAS 7647-01-0) and carbon dioxide (CAS 124-38-9). The assessment is, therefore, based on the available data of the hydrolysis products.
No data on algal toxicity of carbon dioxide (CAS 124-38-9) to aquatic invertebrates are available.
Data for Hydrolysis product - hydrogen chloride (HCL, CAS 7647-01-0):
For the hydrolysis product hydrogen chloride (HCL, CAS 7647-01-0) data from a growth inhibition test according to OECD 201 with the freshwater green algae P. subcapitata are available (OECD SIDS, 2002). In this study a 72-h ErC50 value of 0.492 mg/L (acid equivalent to pH 5.3) and a 72-h NOErC value of 0.097 mg/L (acid equivalent to pH 6) were determined.
Hydrolysis product – butanol (CAS 71-36-3):
For the hydrolysis product butanol (CAS 71-36-3) a number of results from algal toxicity studies are available. The key effect data are a 72-h ErC50 > 1000 mg/L and a 72-h NOErC of 180 mg/L as observed in a study with the freshwater species P. subcapitata. The test was conducted according to OECD guideline 201 and in compliance with GLP criteria and the test concentrations were analytically verified (MOE, Japan; 1996). In addition, several studies with freshwater algae species (D. subspicatus; P. subcapitata) are also available for CAS 71-36-3. According to these supporting data the lowest ErC50 was 225 mg/L and the lowest ErC10 was 134 mg/L, based on initially measured test concentrations (P. subcapitata; OECD 201; Wong et al. 1998, as cited in SIDS 2001).
Assessment:
There are no algal toxicity data available considering the parent compound butyl chloroformate (CAS 592-34-7).
The key study with the hydrolysis product butanol (CAS 71-36-3) comes from a test with Pseudokirchneriella subcapitata. The study was performed according to according to OECD guideline 201; based on growth rate, the 72-h ErC50 was determined to be > 1000 mg/L (nominal), indicating no harmful acute effects (MOE, Japan; 2002). The 72-h NOErC was 180 mg/L
In a study according to OECD 201 (OECD SIDS, 2002),the hydrogen chloride (HCL, CAS 7647-01-0) showed to be acutely very toxic to algae due to the low pH: 72-h ErC50 = 0.492 mg/L (acid equivalent to pH 5.3); 72-h NOErC = 0.097 (acid equivalent to pH 6).
Summary of algal toxicity data:
Compound |
Species |
Results |
Guideline |
Reference |
Hydrolysis product (CAS 7647 -01-0) |
P. subcapitata |
72-h ErC50 = 0.492 mg/L; 72-h NOErC = 0.097 mg/L
(pH-dependent; acid equivalent)
|
OECD 201 |
OECD SIDS (2002) |
Hydrolysis product (CAS 71-36-3) |
P. subcapitata |
72-h ErC50 > 1000 mg/L; 72-h NOErC = 180 mg/L |
OECD 201 |
MOE, Japan (1996) |
Hydrolysis product (CAS 71-36-3) |
div. |
ErC50 >200 mg/L; ErC10 >100 mg/L |
OECD 201 |
OECD SIDS (2001); (summary of div. test results) |
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