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Diss Factsheets
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EC number: 209-750-5 | CAS number: 592-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP non-guideline, available as unpublished report, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- other: English translation (summary)
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
- Principles of method if other than guideline:
- According to BASF-internal standard. The test substance (ca. 0.5 g) was applied to a 2.5 x 2.5 cm application site of white Vienna rabbits for 1 min, 5 min, 15 min and 20 h under occlusive conditions. The skin was left intact. Animals were observed for 8 days and skin changes were observed. Findings were recorded after 24 hours and at the end of the observation period. Findings were graded as described in OECD test guideline 404.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butyl chloroformate
- EC Number:
- 209-750-5
- EC Name:
- Butyl chloroformate
- Cas Number:
- 592-34-7
- Molecular formula:
- C5H9ClO2
- IUPAC Name:
- butyl carbonochloridate
- Details on test material:
- - Name of the test substance used in the study report: n-Butylchlorkohlensaeureester, Chloroformic acid butyl ester
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Weight at study initiation: Male animal 3.24 kg, Female animal 2.53 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- Undiluted
- Duration of treatment / exposure:
- 1 min, 5 min, 15 min, 20 h
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- - The test substance was washed off after the appropriate exposure time with Lutrol/water (1:1)
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1 and #2
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: 5 min, 15 min and 20 hr exposure. Necrosis after 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 5 min, 15 min and 20 hr exposure. Induration after 8 days
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 5 min and 15 min
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 hr exposure. Transverse folds after 8 days
- Irritant / corrosive response data:
- - 1 minute exposure: After 24 hours marked erythema was observed in both animals. These effects were not reversible within 8 days. In addition marked scaling was observed on both animals after 8 days.
- 5 and 15 minute exposure: After 24 hours marked erythema was observed in both animals and slight edema in animal #1. The observed erythema was not reversible within 8 days. In addition necrosis was observed in animal #1 and hardening of the skin in both animals.
- 20 hour exposure: After 24 hours marked erythema was observed in both animals and slight edema in animal #1 and strong edema in animal #2. The observed erythema was not reversible within 8 days. In addition necrosis was observed in both animals and transverse folds were present in the skin in both animals.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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