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EC number: 271-239-8 | CAS number: 68526-91-0 A complex combination of hydrocarbons produced by the distillation of products from the hydrogenation of isotridecanal from the hydroformylation of dodecene. It consists predominantly of C13-14 primary aliphatic alcohols, C22-28 dimer alcohols, C26 acetals and esters, and C>10 acid sodium salts and boils in the range of approximately 250°C to 450°C (482°F to 842°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- (only 4 strains tested)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Dodecene, hydroformylation products, high-boiling
- EC Number:
- 271-239-8
- EC Name:
- Dodecene, hydroformylation products, high-boiling
- Cas Number:
- 68526-91-0
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction products of dodecene, hydroformylation products, high boiling
- Details on test material:
- - Name of test material (as cited in study report): Oxooel 13
- Physical state: yellow, liquid
- Composition of test material, percentage of components: > 80% mixture of aliphatic esters and alcohols in the C range of 26 - 39; 10-20% mixture of diols and monoalcohols in the C13 range
- Lot/batch No.: from storage tank 82
- Storage condition of test material: room temperature
- Other: test substance number: 91/234
Constituent 1
Method
- Target gene:
- his-operon
Species / strain
- Species / strain / cell type:
- S. typhimurium, other: TA1535, TA1537, TA100, TA98
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- Aroclor 1254 induced rat liver (Sprague-Dawley) S9 mix
- Test concentrations with justification for top dose:
- 20-5000 µg/plate
- Vehicle / solvent:
- - solvent used: DMSO
Controls
- Untreated negative controls:
- yes
- Negative solvent / vehicle controls:
- yes
- Remarks:
- (DMSO)
- Positive controls:
- yes
- Positive control substance:
- other: see: "Details on test system and conditions."
- Details on test system and experimental conditions:
- POSITIVE CONTROLS:
with S9 mix; for all strains: 2-aminoanthracene (10 µg/plate);
without S9 mix; for the strains TA100 and TA1535: N-methyl-N'-nitro-N-nitroso-guanidine (5 µg/plate);
without S9 mix; for the strain TA98: 4-nitro-o-phenylendiamine (10 µg/plate)
without S9 mix; for the strain TA98: 9-aminoacridine chloride monohydrate (100 µg/plate)
METHOD OF APPLICATION: in agar (plate incorporation); preincubation
DURATION
- Preincubation period: 20 min
- Exposure duration: 48 hrs (37°C)
REPLICANTS: 3
SELECTION AGENT (mutation assays): Vogel-Bonner-agar
- Evaluation criteria:
- a substance to be characterized as positive has to fulfill following requirements:
- doubling of the spontaneous mutation rate (control)
- dose-response relationship
- reproducibility of the results
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: TA1535, TA1537, TA100, TA98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (depending on the strain and test conditions at doses >/= 2500 µg/plate)
- Vehicle controls validity:
- valid
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- valid
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Standard plate test (20 - 5000 µg/plate) | ||||||
Strain | Metabolic activation system | mean his+ revertant colonies (negative control) | maximum revertant factor (conc. (µg/plate)) | dose dependency | Assessment | maximum revertant factor (positive control) |
TA 98 | no | 25 | 1.1 (20) | no | negative | 55.6 |
yes | 38 | 1.1 (100) | no | negative | 31.8 | |
TA 100 | no | 100 | 1 (100) | no | negative | 21.9 |
yes | 99 | 1.2 (20) | no | negative | 15.3 | |
TA 1537 | no | 13 | 1 (20, 100) | no | negative | 82 |
yes | 16 | 1 (100) | no | negative | 8.9 | |
TA1535 | no | 17 | 1 (500) | no | negative | 118.7 |
yes | 19 | 0.9 (20,100,500) | no | negative | 11.5 | |
Preincubation test (20 - 5000 µg/plate) | ||||||
Strain | Metabolic activation system | mean his+ revertant colonies (control) | maximum revertant factor (conc. (µg/plate)) | dose dependency | Assessment | maximum revertant factor (positive control) |
TA 98 | no | 25 | 0.9 (100) | no | negative | 27.1 |
yes | 37 | 1 (5000) | no | negative | 16.3 | |
TA 100 | no | 105 | 1 (20, 100) | no | negative | 5.5 |
yes | 108 | 1 (20) | no | negative | 5.9 | |
TA 1537 | no | 10 | 1.2 (100) | no | negative | 37.5 |
yes | 13 | 1 (20) | no | negative | 6.2 | |
TA 1535 | no | 16 | 0.9 (100) | no | negative | 60.1 |
yes | 15 | 0.9 (20) | no | negative | 4.5 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
According to the results of the present study, the test substance Oxooel 13 is not mutagenic in the Salmonella typhimurium reverse mutation assay under the experimental conditions chosen here. - Executive summary:
The study is conducted according to the OECD Guideline 471 and is reliable without any restriction (deviation: only 4 strains tested).
Oxooel 13 was tested in the standard plate test as well as in the preincubation assay with and without metabolic activation (MA) in S. typhimurium TA98, TA100, TA1535 and TA1537 at dose levels of 20 -5000 µg/plate. No increase in the number of revertants was detected in any strain with and without MA. Vehicle controls and positive controls were valid. Cytotoxicity was found depending on the strain and test conditions in concentrations >/= 2500 µg/plate.
Conclusion:
According to the results of the present study, the test substance Oxooel 13 is not mutagenic in the Salmonella typhimurium reverse mutation assay under the experimental conditions chosen here.
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