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Diss Factsheets
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EC number: 213-050-5 | CAS number: 919-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1956
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
- Report date:
- 1956
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 3-(triethoxysilyl)propiononitrile
- EC Number:
- 213-050-5
- EC Name:
- 3-(triethoxysilyl)propiononitrile
- Cas Number:
- 919-31-3
- Molecular formula:
- C9H19NO3Si
- IUPAC Name:
- 3-(triethoxysilyl)propanenitrile
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3 to 5 months
- Weight at study initiation: mean 2.5 kg
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- other: undiluted
- Details on dermal exposure:
- TEST SITE
- Area of exposure: the trunk
- Type of wrap if used: "Vinylite" sheeting was used to retain the dose in contact with the clipped skin of the trunk
No other details on dermal exposure available. - Duration of exposure:
- 24 hours
- Doses:
- 5.0 and 10.0 ml/kg bw
- No. of animals per sex per dose:
- 6
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: No details available.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No details available. - Statistics:
- Thompson's method of calculating the LD50 was used.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 753 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals died within one day at the 10.0 ml/kg bw dose level, one animal died on the first day at the 5.0 ml/kg bw dose level.
- Clinical signs:
- other: Skin erythema with slight necrosis in several cases resulted from these covered applications.
- Gross pathology:
- Dosage: 10.0 ml/kg bw: The lungs were slightly congested, the kidneys pale and pitted, and livers mottled.
Dosage: 5.0 ml/kg bw: None reported. - Other findings:
- No other findings reported/available.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred
Dose |
Mortality (# dead/total) |
Time range of deaths (day) |
||
Male |
Female |
Combined |
||
5.0 |
1/3 |
- |
1/3 |
1 |
10.0 |
3/3 |
- |
3/3 |
1 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In an acute dermal toxicity study available from an IUCLID summary, claimed to be conducted using a protocol comparable to the OECD Test Guideline 402 , but predating GLP, the LD50 was determined to be value of 5753 mg/kg bw/day in male New Zealand White rabbits.
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