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EC number: 642-362-8 | CAS number: 1190630-03-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The short-term toxicity in invertebrates of components of Ziegler Bottoms has been documented within this dossier. In a conservative approach the most sensitive study result from across the two primary constituents of Ziegler Bottoms has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the two substances has been identified as a reliable study with docosan-1-ol (Fisk et al. 2009) where the 96 hr LC50 was predicted at >100 mg/L. However, the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the endpoint in question.
Several reliable (Klimisch 1 or 2) short-term toxicity studies in invertebrates have been conducted for constituents of Ziegler Bottoms and are included in this dossier. The reliable studies included for each constituents briefly described below. In a conservative approach the most sensitive study result from across the two constituents will be identified and used to address the hazard endpoint in question.
Icosan-1-ol
There were no reliable measured data for short-term toxicity of icosan-1-ol to invertebrates. However, Fisk et al (2009) provided reliable (Klimisch 2) predicted results for short-term toxicity of icosan-1-ol to invertebrates using a validated QSAR model based on measured data available across the alcohols category and the Log Kow of the substance. Fisk et al. (2009) predicted a 96hr LC50 of >100 mg/L for short ¿term toxicity to invertebrates when exposed to icosan-1-ol. The result was compared to the limit of solubility (LoS) and for this substance the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.102 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
Docosan-1-ol
Fisk et al. (2009) provided reliable (Klimisch 2) predicted results for the short-term toxicity of docoosan-1-ol toDaphnia magnausing a validated QSAR based on measured data available across the alcohols category and the Log Kow of the substance. Fisk et al. (2009) predicted a 96hr LC50 of >100 mg/L for short ¿term toxicity toDaphnia magnawhen exposed to docosan-1-ol. The result was compared to the limit of solubility (LoS) and for this substance the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
The short-term toxicity in invertebrates of components of Ziegler Bottoms has been documented within this dossier. Adequate reliable predicted data exists for short-term toxicity to invertebrates to components of Ziegler Bottoms (namely, icosan-1-ol and docosan-1-ol). In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the two substances has been identified as a reliable study with docosan-1-ol (Fisk et al., 2009) where the 96 hr LC50 was predicted at >100 mg/L. However, the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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