Registration Dossier
Registration Dossier
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EC number: 211-089-2 | CAS number: 629-40-3
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Readily biodegradable.
Key value for chemical safety assessment
Additional information
The inherent biodegradation potential of the test substance has been assessed in a guideline study according to OECD 302B with non-adapted activated industrial sludge as inoculum [BASF AG, 1985]. At test termination after 16 d a degradation level of 97 % has been reached. Since the pass level of 70% degradation was exceeded after 2.5 days already and the lag phase was determined to be less than 1 day, it can be concluded that the test substance is not only inherently biodegradable but also easily eliminated from water.
For assessing the ready biodegradability, a GLP guideline study of a close structural analogue (CAS 111 -69 -3, adiponitrile) to the test substance has been consulted since there is no data available for suberonitril [BASF AG, 2002]. Both chemicals (suberonitrile and adiponitrile) are aliphatic dinitriles belonging to the same homologous series as they only differ in the number of atoms in the carbon chain (i.e. suberonitrile = 8 C-atoms, adiponitrile = 6 C-atoms) and are therefore suitable analogue substances.
During the biodegradation study which was conducted according to OECD guideline 301A, a degradation of the analogue substance > 90 % (DOC removal) after 28 days was observed which indicates ready biodegradability.
Additional information from model calculations with OASIS Catalogic v5.11.5 provide biodegradation rates of 83.9 % for adiponitrile as well as for suberonitrile. The domain similarity is 100 %. This shows that suberonitrile is not only readily biodegradable itself but indeed shows similar biodegradation behaviour as adiponitrile which further justifies the read-across apporach.
Therefore, suberonitrile is considered to be readily biodegradable.
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