Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 202-770-5 | CAS number: 99-59-2
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for LC50 read across evaluation for 99-59-2
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR Toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 2.3.
- GLP compliance:
- no
- Test type:
- other: Acute Rodent Inhalation Toxicity Test
Test material
- Reference substance name:
- 5-nitro-o-anisidine
- EC Number:
- 202-770-5
- EC Name:
- 5-nitro-o-anisidine
- Cas Number:
- 99-59-2
- Molecular formula:
- C7H8N2O3
- IUPAC Name:
- 2-methoxy-5-nitroaniline
- Details on test material:
- Name of the test material: 5-nitro-o-anisidine
Molecular formula: C7H8N2O3
Substance type: Organic
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Wistar;Sprague-Dawley;CnR-CD;Long-Evans
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: Inhalation: Vapor
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 218.23
- Based on:
- test mat.
- Exp. duration:
- 4 h
Any other information on results incl. tables
The prediction was based on dataset comprised from the following descriptors: LC50
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
("a" and ("b" and "c" ) )
Domain logical expression index: "a"
Similarity boundary:Target: c1(OC)c(N)cc(N(=O)=O)cc1
Threshold=50%,
Dice(Atom pairs)
Domain logical expression index: "b"
Parametric boundary:The target chemical should have a value of log Kow which is >= 0.347
Domain logical expression index: "c"
Parametric boundary:The target chemical should have a value of log Kow which is <= 3.45
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information
- Conclusions:
- The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
- Executive summary:
The 4h acute inhalation median lethal concentration (LC50) of 5-nitro-o-anisidine in rat was estimated to be 218.23 mg/L. Acute inhalation toxicity of 5-nitro-o-anisidine to rat by inhalative route indicates that the substance does not exhibits acute toxicity by the inhalative route.
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