Registration Dossier
Registration Dossier
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EC number: 204-707-7 | CAS number: 124-64-1
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: sub-chronic oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- data not available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (only a summary is available)
Data source
Reference
- Reference Type:
- publication
- Title:
- neurotoxic evaluation of tetrakis hydroxymethylphosphonium chloride in fischer 344 rats
- Author:
- Thake D, Kurtz P and Carter S
- Year:
- 1 982
- Bibliographic source:
- The toxicologist, Abstract 407, p. 115.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats were exposed daily via oral gavage to test chemical for 45 or 90 days. Neurobehavioral evaluations were conducted after 45 and again after 90 days. Brains, spinal cords and peripheral nerves were evaluated.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- EC Number:
- 204-707-7
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- Cas Number:
- 124-64-1
- Molecular formula:
- C4H12O4P.Cl
- IUPAC Name:
- tetrakis(hydroxymethyl)phosphonium chloride
- Details on test material:
- - Name of test material (as cited in study report): Tetrakis hydroxymethyl phosphonium chloride
No other data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 45 or 90 days
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40 or 80 mg/kg/day
Basis:
nominal conc.
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 40 mg/kg bw/day (nominal)
- Sex:
- female
- Remarks on result:
- other:
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this test, THPC induced neurotoxicity in Fischer 344 rats.
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