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EC number: 204-707-7 | CAS number: 124-64-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- end 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to recognized guidelines, with acceptable restrictions. GLP not stated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 987
- Report date:
- 1987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- no necropsies were performed
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- EC Number:
- 204-707-7
- EC Name:
- Tetrakis(hydroxymethyl)phosphonium chloride
- Cas Number:
- 124-64-1
- Molecular formula:
- C4H12O4P.Cl
- IUPAC Name:
- tetrakis(hydroxymethyl)phosphonium chloride
- Details on test material:
- - Name of test material (as cited in study report): Tetrakis(hydroxymethyl)phosphonium chloride (THPC) from Aceto Chemical Company (Flushing, New York)
- Analytical purity: 75 % (determined by iodate-thiosulfate titration, elemental analysi, and thin -layer chromatographic analyses)
- Storage condition of test material: 23°C
- Lot/batch No.: ON2
No other data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories (Portage, MI)
- Age at study initiation: 7 week-old
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: five per cage (Polycarbonate (Lab Products, Inc., Rochelle Park, NJ). Bedding: Absorb-Dri (Lab Products, Inc. Garfield, NJ)
- Diet: Purina 5001 Lab Chow, pelleted (Ralston Purina, St. Louis, MO); available ad libitum
- Water: Freely available; automatic watering system (Edstrom Industries, Waterford, W)
- Acclimation period: 17 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21-23
- Humidity (%): 40-60
- Air changes (per hr): 15
- Photoperiod: 12 hrs dark / 12 hrs fluorescent light
IN-LIFE DATES: From: 30 october 1978 To: 13 november 1978
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: deionized water
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5 ml/kg
- Doses:
- 75, 150, 300, 600 or 1,200 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observed 2 x day
- Necropsy of survivors performed: no
- Other examinations performed: no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 185 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 141 - 242
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 161 mg/kg bw
- Based on:
- act. ingr.
- 95% CL:
- 115 - 224
- Mortality:
- All male and female rats that received 600 or 1200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2.
At 150 mg/kg, 1/5 (male) and 2/5 (female) died. - Clinical signs:
- other: Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing.
- Gross pathology:
- Necropsies were not performed.
Any other information on results incl. tables
Table 1: Number of animals dead and time range within which mortality occurred
Mortality (# dead/ total) | ||||
Dose mg/kg bw | male | female | combined | Time range of deaths (days) |
75 | 0/5 | 0/5 | 0/10 | - |
150 | 1/5 | 2/5 | 3/10 | (1 -4) |
300 | 5/5 | 5/5 | 10/10 | (2 -13) |
600 | 5/5 | 5/5 | 10/10 | 2 |
1200 | 5/5 | 5/5 | 10/10 | 2 |
All male and female rats that received 600 or 1,200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2. Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing. Final weights were not recorded. Necropsies were not performed.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Under the conditions of this test, THPC is classified as Acute toxicity Category 3 according to regulation (EC) 1272/2008.
- Executive summary:
In a single-administration studies (NTP, 1987), groups of five F344/N rats of each sex were administered a single dose of 75, 150, 300, 600 or 1200 mg/kg THPC in deionized water by gavage. Animals were observed for 14 days. All male and female rats that received 600 or 1200 mg/kg THPC and all males that received 300 mg/kg THPC were dead by day 2. At 150 mg/kg bw, one male and two females died. Surviving rats of each sex that received 150 mg/kg had reddish fluid around the nostrils by day 3 and labored breathing. Final weights were not recorded. Necropsies were not performed.
Oral LD50 females is 161 mg/kg bw (115 -224) and oral LD50 males is 185 mg/kg (141 -242).
THPC is classified toxic by ingestion according to EU criteria and Acute toxicity Category 3 according to regulation (EC) 1272/2008, based on the male and female LD50.
This acute oral study is classified as acceptable and satisfies the guideline requirement for an acute oral study in the rats.
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