Registration Dossier
Registration Dossier
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EC number: 210-539-5 | CAS number: 617-94-7
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary references
Data source
Materials and methods
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Repeated dose |
Data lacking No valid studies are available. The available study gets a K4 since no original references are available only secondary references.
Classification and Labeling Since only secondary references are available the data is not sufficient for C&L purposes. |
No cumulative effects were observed in rats receiving daily oral doses of 1/5 LD50 (450 mg/kg) for 1 month
|
Bukhalovskii, A. A. & Shugaev, B. B. (1976). Toksichnost i gigienicheskoe normirovanie izoforona, digidroizoforona i dimetilfenilkarbinola.Promyshlennost Sillleticheskogo Kauchuka1976 (2), 4. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982 |
A combination of six compounds, including was given to male rats, presumably in the drinking-water, in order to study the effect on blood-tissue barrier permeability
Mixtures containing the maximum permissible concentration (MPC) or 1/3 MPC of each compound were given for 9 months. The MPC was stated to be 0·05 mg/liter. Following administration of ACTH and32P to the treated rats, significant disturbances in catalase activity and ascorbic acid content in the blood were demonstrated, as well as a decrease in the permeability of the blood-tissue barrier of the endocrine glands. |
Smirnova, R. D., Novikov, Yu. V., Yudina, T. V., Kos'mina, L. F. & Tambovtseva, A. M. (1971). Izuchenie pronitsaemosti gisto-gematicheskikh bar'erov i nekotorykh biokhimicheskikh pokazatelei pri kombinirovannom deistvii summy veshchestv.Gig. San it.36 (7), 19. Cited in:Food and Chemical Toxicology. Vol. 20, Pg. 675, 1982 |
Applicant's summary and conclusion
- Conclusions:
- No valid studies are available. The available studies get a K4 since no original references are available only secondary references. Since only secondary references are available the data is not sufficient for C&L purposes.
- Executive summary:
No valid studies are available. The available studies get a K4 since no original references are available only secondary references. Since only secondary references are available the data is not sufficient for C&L purposes.
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