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EC number: 273-732-3
CAS number: 69012-32-4
By-product of smelting of phosphate rock, silica and coke in manufacture of phosphorus.
2 days after intratracheal instillation, SEM analysis showed fibers in
the main bronchi, on the epithelium of the distal segments of bronchiole
and in alveoli. There were no large agglomerations of fibers. This
indicates an even distribution of the fibers in the lungs.
After 2 days, 0.6 to 2 mg wollastonite was present in the lungs, which
could be calculated from the shape and density of particles. After six
months the relative mass of the test material was found to be 0.02 to
0.5% of the initial lung burden. The elimination of fibers follows first
order kinetics, with half-times between 15 and 24 days.
Wistar rats were exposed to wollastonite via intratracheal instillation
into the lungs. The distribution of the test substance in the lung was
analysed by scanning electron microscopy after 2 and 14 days, 1, 3, and
6 months to determine elimination kinetics.
The elimination kinetics of wollastonite fibers from the lung were
relatively fast, with half-times of 15 to 21 days. For the thoracic
fraction of wollastonite, the elimination from the lung was as fast as
for the respirable particulate fraction. This suggests that mechanical
clearance mediated by macrophages could be only of minor importance for
wollastonite, for which dissolution of fibers must be the important
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