Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 270-298-7 | CAS number: 68424-37-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Worst-case NOEC (21 d) expected to be 0.31 mg/L (nominal) based on effects of the pure homologue C14 fatty acid.
Key value for chemical safety assessment
Additional information
For the members of the fatty acid category four chronic tests are available conducted with pure homologues of different chain lengths. The tested homologues were: decanoic acid (C10 - CAS 334-48-5), lauric acid (C12 - CAS 143-07-7), myristic acid (C14 - CAS 544-63-5) and palmitic acid (C16 - CAS 57-10-3). As myristic acid (C14) and palmitic acid (C16) are main components of the fatty acid mixture under consideration a read-across is performed to these pure homologues. The linked studies were used in a weight of evidence approach for the evaluation of effects of the mixture on aquatic invertebrates. The available NOEC-values are summarized in the following table.
Fatty acid homologue |
NOEC (as reported in the study) |
Water solubility* |
Test design and species |
Reference |
C14 - CAS 544-63-8 myristic acid |
0.31 mg/L (measured, twa concentrations) |
< 0.13 at 20 °C |
21 d, semi-static,Daphnia magna |
NITE, 2003c |
C16 - CAS 57-10-3 palmitic acid |
0.22 mg/L (measured, twa concentrations) |
< 0.05 at 20 °C |
21 d, semi-static,Daphnia magna |
NITE, 2008 |
C18 - CAS 57-11-4 stearic acid |
-- |
insoluble |
No chronic test available |
* see category justification
Myristic acid (C14: CAS 544 -63 -8) was tested in a chronic test according to OECD 211 in compliance with GLP over 21 days (NITE, 2003c). In the study the limit of water solubility under test conditions is reported to be 0.34 mg/L. Due to the low water solubility, a solvent was used to presolve the test material. Different concentrations were tested using a semi-static test design. The study resulted in a measured NOEC of 0.31 mg/L. Thus within the water solubility range given in the study no adverse effects of the test substance on reproduction could be determined. Nevertheless chronic effects of myristic acid cannot completely be excluded as for the test concentration of 0.45 mg/L (measured) and above significant effects are described. Although, chronic effects of myristic acid on daphnids are unlikely to occur, even under consideration of the experimental determined water solubility of < 0.13 mg/L reported for the pure homologue (see category justification) the reported NOEC is taken into account for the evaluation of toxicity of the considered mixture.
For the evaluation of chronic effects of palmic acid (C16: CAS 57 -11 -4) on aquatic invertebrates, daphnids were tested in a limit-test over a period of 21 days (NITE, 2008). The semi-static experiment was conducted according to OECD 211 in compliance with GLP-requirements. The used test concentration of 0.51 mg/L (nominal) corresponding to a mean measured value (time weighted mean) of 0.22 mg/L were above the reported water solubility limit. No effects could be observed on daphnids at this test concentration and thus the NOEC is reported to be 0.22 mg/L.
Concluding from the results reported for the pure fatty acid homologues C14 and C16 a worst-case NOEC of 0.31 mg/L is assumed for the considered mixture.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.