3-methoxy-3-methylbutan-1-ol

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2001

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

The main study was not conducted as preliminary tests indicated that the substance was stable under the given conditions.

Qualifier:

according to guideline

Guideline:

OECD Guideline 111 (Hydrolysis as a Function of pH)

GLP compliance:

yes

Transformation products:

no

pH:

4

Temp.:

25 °C

DT50:

> 1 yr

Key result

pH:

7

Temp.:

25 °C

DT50:

> 1 yr

pH:

9

Temp.:

25 °C

DT50:

> 1 yr

Test results:

Test solution	Initial concentration (mg/L) Measured value	Concentration after 5 days (mg/L)	Residual rate (%)
			Measured value	Mean
pH 4	202	202	100	99.0
		198	97.9
pH 7	204	194	95.0	96.7
		201	98.4
pH 9	188	195	104	105
		199	106

The substance was stable in water and its half-life at 25°C was greater than 1 year at pH 4, 7 and 9.

Validity criteria fulfilled:

not applicable

Conclusions:

In conclusion, preliminary tests indicate that the substance is stable in water having a half-life of more than a year at pH 4, 7 and 9 and 25°C.

Description of key information

Hydrolysis half-life: stable in water (t 1/2 > 1 yr at 25°C)

Key value for chemical safety assessment

Half-life for hydrolysis:

1 yr

at the temperature of:

25 °C

Additional information

Hydrolysis half-lives were determined at pH 4, 7 and 9 at 50°C in a reliable preliminary study conducted according to an appropriate test protocol and in compliance with GLP. Hydrolysis half-lives were found to be greater than one year at 25°C and pH 4, 7 and 9. The result is considered to be reliable.