Registration Dossier
Registration Dossier
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EC number: 247-156-8 | CAS number: 25640-78-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
No mutagenic potential observed in in-vitro bacterial as well as mammalian mutagenicity tests.
Short description of key information:
MIPB (CAS no. 25640-78-2) showed no mutagenic potential in the Ames test (Brusick 1976).
In tests together with other solvents, no evidence of mutagenicity was found:
As part of a comprehensive testing programme including neat MIPB and MIPB in mixture, a single tier testing of MIPB in combination with other solvents (mixtures of mono- and diisopropylbiphenyl) has given no indication of a mutagenic reaction.
These tests included:
1. Salmonella typhimurium (AMES) Mammalian Microsome Plate Incorporation Study (not shown);
2. Mouse Lymphoma Forward Mutation Assay;
3. In Vitro Chromosome Aberrations in Chinese Hamster Ovary Cell (CHO).
Furthermore, DIPB (diisopropylbiphenyl), a structure-related substance, supported the findings with MIPB formulations.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No classification required based on negative results from the mutagenicity battery performed with MIPB and structure-related compounds.
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