Registration Dossier
Registration Dossier
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EC number: 956-606-9 | CAS number: 1373821-23-8
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
OCDE 203, key study, validity 2:
96h-LC50 = 5.7 mg/L (95% CL: 3.1-10.4 mg/L).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Dose descriptor:
- LC50
- Effect concentration:
- 5.7 mg/L
Additional information
To assess the short term toxicity of the registered substance to fish, one data point is available
This value (phytosafe, 2012) is assessed as a key datapoint. The acute toxicity of the test item to zebra fish was conducted according to OECD 203 "Fish acute toxicity test".
In an acute aquatic toxicity study performed in accordance with OECD guideline 203 and GLP, groups (7/dose) of zebra fish (Brachydanio rerio) were exposed to test substance at concentrations of 0 (control), solvent control (acetone), 3.4, 5.0, 7.5, 11.2 and 16.7 mg/L (nominal) for 96 hours under static conditions. Mortality was recorded at 24, 48, 72 and 96 hours. A preliminary range-finding test was also conducted on 7 fish/ dose at 0.01, 0.1, 1.0, 10.0 and 100.0 mg/L and animals were observed for 96 hours.
Mortalities (96 hour) at 0 (control), solvent control (acetone), 3.4, 5.0, 7.5, 11.2 and 16.7 mg/L were 0, 0, 0, 42.9, 85.7, 100 and 100%, respectively. LC50 values at 24, 48, 72 or 96 hours were calculated to be 8.0 (4.7-13.8), 6.1 (4.8-7.9), 5.7 (3.1-10.4) or 5.7 (3.1-10.4) mg/L, respectively. NOEC at 96 hours was considered to be 3.4 mg/L.
Under the test conditions, the 96 hour LC50and NOEC for test substance is 5.7 and 3.4 mg/L in zebra fish (Brachydanio rerio), respectively.
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