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Diss Factsheets
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EC number: 240-015-1 | CAS number: 15879-01-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- Study meets generally accepted scientific principles, well documented, according to national australian guideline wich is comparable to more widespread used guidelines. acceptable for assessment.
- Justification for type of information:
- Read across
- Qualifier:
- according to guideline
- Guideline:
- other: New South Wales Gouvernment Environment Protection Authority: ASTM Designation E1192 (1988)
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Triethanolamine
- Analytical purity: no data
- stored in the dark at 22±2 °C - Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: stock solutions, stirred in the dark; diluted to the appropriate concentrations immediately prior to the commencement of the test.
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): no - Test organisms (species):
- Ceriodaphnia dubia
- Details on test organisms:
- TEST ORGANISM
- Common name: Ceriodaphnia cf. dubia
- Source: laboratory
- Age at study initiation (mean and range, SD): < 24 h
- Method of breeding: cultures were maintained in 2-L glass beakers and transferred to fresh water three times weekly. Food was provided after water renewal (unicellular algae: Pseudokircheneriella subcapitata and Ankistrodesmus sp., each at 25000 cells/mL)
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 23±1 °C
- Nominal and measured concentrations:
- series of 5 test concentrations plus control
- Details on test conditions:
- TEST SYSTEM
- Test vessel: beakers
- Material, size, headspace, fill volume: 250-mL glass beakers, fill volume: 200 mL
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 3
- No. of vessels per control (replicates): 3
- Biomass loading rate: 1 animal / 40 mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: dechlorinated tapwater, filtered (1 µm), aged (1 month), adjusted to 500 µS/cm with seawater
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8 h light:dark cycle
- Light intensity: 1000 lux at surface
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
- measurements:
- number of immobile cladocera counted at the end of test
- pH, dissolved oxygen, conductivity at test initiation before test animals were added and at test completion
TEST CONCENTRATIONS
- Spacing factor for test concentrations: no data
- Justification for using less concentrations than requested by guideline: not applicable
- Range finding study: performed
- Test concentrations: no data - Reference substance (positive control):
- not specified
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 609.88 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 95% confidence interval 565.2 mg/l - 658.3 mg/l
- Remarks:
- The 48-h EC50 (immobilisation) values and the corresponding 95 % confidence intervals were based on nominal concentrations and were determined by the trimmed Spearman-Kaerber method (Hamilton et al., 1977).
- Validity criteria fulfilled:
- yes
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- RA
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Annual Book of ASTM Standards: Water and Environmental Technology. Vol 1104, (1994)
- Principles of method if other than guideline:
- Annual Book of ASTM Standards: Water and Environmental Technology. Vol 1104, (1994)
- GLP compliance:
- not specified
- Analytical monitoring:
- no
- Vehicle:
- yes
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 80-100 mg/l CaCO3
- Test temperature:
- 20.5 -22C
- pH:
- 8.1-9.4
- Dissolved oxygen:
- 7.6 - 8.5
- Nominal and measured concentrations:
- 31.2, 62.5, 125, 250, 500 mg/l
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 230 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 125 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Conclusions:
- 48 h LC50= 233 mg/L (nominal; static)
48 h LC50= 230 mg/L (nominal; static)
Referenceopen allclose all
Description of key information
Testing was considered not necessary as alternatives to testing were available and they demonstrated to be sufficient to fulfil the legal requirements related to Annex VII, Section 9.1.1 of REACH. Therefore, the general rules for adaptation 1.2 of Annex XI of REACH regulation are met and applied. The results obtained from the three publications available from were in the EC50 range 609 -125 mg/l. the EC50 of 125 mg/l has been chosen as key for the CSA.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 125 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.