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EC number: 237-706-5 | CAS number: 13933-32-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data (report dated 24 May 1977)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable published method available at the time of the study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Protocol as described by Magnusson B and Kligman AM (Journal of Investigative Dermatology (1969), 52, 268-276)
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- Study conducted in 1977
Test material
- Reference substance name:
- Tetraammineplatinum dichloride
- EC Number:
- 237-706-5
- EC Name:
- Tetraammineplatinum dichloride
- Cas Number:
- 13933-32-9
- Molecular formula:
- Cl.1/2H12N4Pt
- IUPAC Name:
- Tetraammineplatinum dichloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): tetraammine platinous chloride
- Substance type: white powder
- Physical state: solid
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: stored in plastic container; no further details
- Other:
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- other: albino
- Sex:
- male
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Porcellus Animal Breeding Limited
Heathfield
Surrey, UK
- Age at study initiation: no data
- Weight at study initiation: 300-350 g
- Housing: individual
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 ± 1
- Humidity (%): 50-70
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): “controlled”
IN-LIFE DATES: From: To:
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
Challenge
- Route:
- epicutaneous, occlusive
- Vehicle:
- water
- No. of animals per dose:
- 10 males
- Details on study design:
- RANGE FINDING TESTS:
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: one by injection; one by topical application 1 week later
- Exposure period:
- Test groups: one
- Control group: no data
- Site: shoulder region
- Frequency of applications: once
- Duration: topical application, 48 hr
- Concentrations: 5% by injection; neat for topical application
B. CHALLENGE EXPOSURE
- No. of exposures: one
- Day(s) of challenge: 14 days after topical induction
- Exposure period: 24 hr
- Test groups: one
- Control group: no data
- Site: flank
- Concentrations: neat
- Evaluation (hr after challenge): 24 and 48 hr
OTHER: - Positive control substance(s):
- not required
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: 1st and 2nd readings
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- Challenge dose – neat
- No. with + reactions:
- 0
- Total no. in group:
- 10
- Clinical observations:
- No data
- Remarks on result:
- other: Reading: other: 1st and 2nd readings. . Hours after challenge: 24.0. Group: test group. Dose level: Challenge dose – neat. No with. + reactions: 0.0. Total no. in groups: 10.0. Clinical observations: No data.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Tetraammine platinous chloride did not induce sensitization in a GPMT, in which a group of ten male guinea pigs were dermally challenged with the neat test compound following a two-stage induction with 5% by intradermal injection and topical application of the neat substance.
- Executive summary:
The skin sensitising potential of tetraammine platinous dichloride was investigated in a guinea pig maximisation test conducted according the method of Magnusson and Kligman (as described in OECD Test Guideline 406).
A group of ten male animals were treated in the shoulder area by intradermal injection with 5% of the test compound, followed 7 days later by a 48-hr topical occluded application of the neat substance. A challenge dose of the neat substance was applied topically to the flank region 14 days later and examined for sensitisation reactions after 24 and 48 hr.
No positive reactions were evident. Hence, tetraammine platinous chloride did not induce sensitisation in this test.
Based on the results of this study, no classification for skin sensitisation is required according to EU CLP criteria (EC 1272/2008).
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