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EC number: 203-965-8 | CAS number: 112-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- between 10 and 28 June 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No test surrogate or analogue material - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: Limit of solubility (LS) (0-24 h), LS/1.78 (0-72 h), LS/3.16, LS/5.62, LS/10, and LS/17.8
- Sampling method: 5 mL taken from the new and aged test solutions
- Sample storage conditions before analysis: at -20°C - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: preparation of a stock solution of nominal 100 mg/L by stirring an appropriate amount of test substance and test water for approximately 1 day. Since still particles were occurred in the solution at the end of the stirring period, the solution was 0.45 µm filtered resulting in a saturated stock solution (LS).
- Differential loading: The LS was further diluted with test water to provide a geometric series of concentration.
- Controls: test water
- Chemical name of vehicle (organic solvent, emulsifier or dispersant): none
- Evidence of undissolved material (e.g. precipitate, surface film, etc): none visible due to 0.45 µm filtration - Test organisms (species):
- Oncorhynchus mykiss (previous name: Salmo gairdneri)
- Details on test organisms:
- TEST ORGANISM
- Common name: rainbow trout
- Strain: --
- Source: in-house culture at CIT from eggs obtained from Viviers de France, Piscicultures des Fontaines, Sarrance, F
- Age at study initiation (mean and range, SD):
- Length at study initiation (length definition, mean, range and SD): average 43.9 mm (40 - 50 mm), n = 70
- Weight at study initiation (mean and range, SD): average 0.90 g, n = 10
- Method of breeding: filtered and dechlorinated potable water softened by Permo water softener system of which 50% were pased through a deionizer producing ultra-pure water
- Feeding during test : none
ACCLIMATION
- Acclimation period: breeding until test start
- Acclimation conditions (same as test or not): yes
- Type and amount of food: trout chow
- Feeding frequency: twice daily ceasing 24 hours before test start
- Health during acclimation (any mortality observed): no abnormalities reported
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Post exposure observation period:
- No post exposure observation period
- Hardness:
- 139 - 154 mg/L as CaCO3
- Test temperature:
- 14.0 - 16.0°C
- pH:
- 7.58 - 8.07
- Dissolved oxygen:
- 6.5 - 10.0 mg/L (> 60% saturation)
- Salinity:
- Test was performed in freshwater.
- Nominal and measured concentrations:
- Limit of solubility (LS): 83.5 mg/L at test start; 81.5 mg/L at 23.9 h => geo.mean 0-23.9h = 82.5 mg/L;
LS/1.78 : 45.5-55.8 mg/L in fresh medium; 38.2-50.6 mg/L in aged test medium => geo.mean 0-71.9 h = 47.8 mg/L
LS/3.16 : 23.4-36.3 mg/L in fresh medium; 22.5-38.7 mg/L in aged test medium => geo.mean 0-96 h = 30.1 mg/L
LS/5.62 : 12.0-21.9 mg/L in fresh medium; 12.2-19.5 mg/L in aged test medium => geo.mean 0-96 h = 15.8 mg/L
LS/10 and LS/17.8 : < LOQ of 5 mg/L during whole test period - Details on test conditions:
- TEST SYSTEM
- Test vessel: not specified in the report
- Aeration: none
- Type of flow-through (e.g. peristaltic or proportional diluter): none
- Renewal rate of test solution (frequency/flow rate): at 24-hour intervals
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
- No. of vessels per vehicle control (replicates): not applicable
- Biomass loading rate: 0.90 g/L
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: filtered and dechlorinated potable water softened by Permo water softener system of which 50% were pased through a deionizer producing ultra-pure water
- Ca/Mg ratio: 4 : 1
- Culture medium different from test medium: no
- Intervals of water quality measurement: at the start and end of each water renewal interval
OTHER TEST CONDITIONS
- Adjustment of pH: not specified
- Photoperiod: 16:8 h light:dark
- Light intensity: not specified
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
Mortality and behavoural changes, at least every 24-hours but more frequently during the first 24 h
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.78
- Justification for using less concentrations than requested by guideline: not applicable
- Range finding study
- Test concentrations: LS, LS/10, LS/100, LS/1000,LS/10000
- Results used to determine the conditions for the definitive study: yes; all fish dead at LS but no effects at lower levels. - Reference substance (positive control):
- no
- Duration:
- 24 h
- Dose descriptor:
- LC50
- Effect conc.:
- 53.7 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 22.9 - 82.5
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- 40.5 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 26.9 - 82.5
- Duration:
- 72 h
- Dose descriptor:
- LC50
- Effect conc.:
- 36.6 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 32.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 95% CL: 15.8 - 47.8
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 15.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 47.8 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- - Behavioural abnormalities: In the LS, LS/1.78 and LS/3.16 some fish were lying on the bottom of the aquarium and/or showing severe loss of equilibrium, abnormal respiratory rate and immobilization before death.
- Observations on body length and weight: not determined
- Mortality of control: none
- Other adverse effects control: none - Reported statistics and error estimates:
- Probit analysis; confidence interval limits were calculated according to Fieller's method.
- Sublethal observations / clinical signs:
Table 1: Acute toxicity of undecylenic acid to rainbow trout - mortality data
Observation Treatment (Dilution of stock solution* / geometric mean measured conc. 0- 96 h) - Number of dead fish / % dead fish time (h) Control / -- LS/17.8 / < 5 mg/L LS/10 / < 5 mg/L LS/5.62 / 15.8 mg/L LS/3.16 / 30.1 mg/L LS/1.78 / 47.8 mg/L LS / 82.5 mg/L 4 0 0 0 0 0 0 0 24 0 0 0 0 0 1 / 10 10 / 100 48 0 0 0 0 0 8 / 80 10 / 100 72 0 0 0 0 0 10 / 100 10 / 100 96 0 0 0 0 3 / 30 10 / 100 10 / 100 * LS = limit of solubility obtained from an initial loading rate of 100 mg/L; LS/xx = dilution of LS
- Validity criteria fulfilled:
- no
- Remarks:
- see free text in section "overall remarks"
- Conclusions:
- The 96 -hour LC50 was calculated as 32.3 mg/L based on geometric mean measured concentrations.
- Executive summary:
In an acute toxicity test, rainbow trout were exposed to the test substance undecylenic acid for 96 hours under semi-static conditions. The test was conducted in accordance with OECD Guideline 203. Mortality and sublethal effects were found only at the three highest treatment levels. A 96 -hour LC50 of 32.3 mg/l was calculated based on geometric mean measured concentrations.
Reference
Description of key information
In an acute toxicity test, rainbow trout were exposed to the test substance undecylenic acid for 96 hours under semi-static conditions. The test was conducted in accordance with OECD Guideline 203. Mortality and sublethal effects were found only at the three highest treatment levels. The 96-hour LC50 was equal to 32.3 mg/l, based on geometric mean measured concentrations.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 32.3 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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