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EC number: 223-453-8 | CAS number: 3900-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short term toxicity to Fish :
Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 39004506 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
LC50 |
15.18299 mg/l |
mortality |
96 hrs |
Lepomis macrochirus |
Predicted data for target chemical |
2 |
LC50 |
42.9921 mg/l |
mortality |
96 hrs |
Oncorhynchus mykiss |
Predicted data for target chemical |
3 |
LC50 |
5.21 mg/l |
mortality |
96 hrs |
Pimephales promelas |
Data from DEPAof CAS NO 93-08-3 |
4 |
LC50 |
15.2 mg/l |
mortality |
48 hrs |
Pimephales promelas |
Data from study report for CAS NO 119-61-9 |
5 |
EC50 |
14.9 mg/l |
mortality |
24 hrs |
Pimephales promelas |
Data from study report for CAS NO 119-61-9 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC50 values was found to be in range of 5.21 to42.9921mg/l in 96 hrs and 48 hrs and the EC50 value was found to be 14.9 mg/l in 24 hrs on the basis of mortality effect . But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.Thus considering the CLP Criteria for aquatic classification of the substance,, it is concluded that 1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit short term toxicity to fish (Lepomis macrochirus,Oncorhynchus mykiss and Pimephales promelas)
Longterm toxicity to fish:
According to column I of Annex IX, Long-term toxicity testing on fish need not to be conducted as it is already provided as part of Annex VIII requirements.Therefore this study was considered to be waived.
Toxicity to aquatic Invertebrate :
Based on the various studies available with Klimish rating 2 and 4 for target chemical CAS NO 3900-45-6 and the read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
LC50 |
23.43862 mg/l |
mortality |
24 hrs |
Daphnia magna |
Predicted data for target chemical |
2 |
EC50 |
44.11281 mg/L.
|
mortality |
48 hrs |
Daphnia magna |
Predicted data for target chemical |
3 |
LC50 |
15.76 mg/L.
|
mortality |
48 hrs |
Daphnia longispina |
Data is from DEPA |
4 |
LC50 |
82 mg/L.
|
mortality |
48 hrs |
Daphnia longispina |
Data from publication for CAS no 22204-53-1 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 15.76 to 82 mg/l and EC50 value was found to be44.11281 mg/l in a 48 hrs study on the basis of mortality effect. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.
Thus considering the CLP Criteria for aquatic classification of the substance it is concluded that the substance 1-(6-methoxy-2-naphthyl) ethan-1-one is not toxic to aquatic invertebrate (Daphnia magna, Daphnia longispina)
Long term toxicity to aquatic invertebrate:
According to column I of Annex IX, Long-term toxicity testing on aquatic invertebrate need not to be conducted as it is already provided as part of Annex VIII requirements.Therefore this study was considered to be waived.
Toxicity to aquatic Algal :
Based on the various studies available with Klimish rating 2 and 4 for the target substance CAS NO 3900-45-6 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
EC50 |
24.74008 mg/l |
growth |
72 hrs |
Pseudokirchneriella subcapitata |
Predicted data for target chemical |
2 |
EC50 |
12.25381 mg/l |
population |
72 hrs |
Pseudokirchneriella subcapitata |
Predicted data for target chemical |
3 |
EC50 |
34.86615mg/l |
- |
- |
Seleriastrum Capricornutum |
Data is from DEPA |
4 |
EC50 |
42mg/l |
mortality |
24 hrs |
Chlorella vulgaris |
Data from publication for CAS no 22204-53-1 |
5 |
EC50 |
40 mg/l |
mortality |
24 hrs |
Ankistrodesmus falcatus |
Data from publication for CAS no 22204-53-1 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that EC50 value is expected to be in range of12.25381 to42 mg/l in 24 hrs to 72 hrs study on the basis of growth, population and mortality effect. But the BCF value of 1-(6-methoxy-2-naphthyl)ethan-1-one reported was not >= 2000 as well as the substance was found to be rapidly degradable.
Thus considering the CLP Criteria for aquatic classification of the substance, it is concluded that1-(6-methoxy-2-naphthyl) ethan-1-one does not exhibit toxicity to green algae (Pseudokirchnerella subcapitata, Chlorella vulgaris, Ankistrodesmus falcatus and Seleriastrum Capricornutum.)
Toxicity to microorganism:
Based on the various studies available with Klimish rating 2 for the target substance CAS NO 3900-45-6 and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows
Sr.No |
Endpoint |
Effect values |
Basis for effects |
Duration |
Species |
Remarks |
1 |
IC50 |
108.7335 mg/l |
Population |
48 hrs |
Tetrahymena pyriformis |
Predicted data for target chemical |
2 |
IGC50 |
25.04128 mg/l |
growth |
48 hrs
|
Tetrahymena pyriformis |
Predicted data for target chemical |
3 |
IGC50
|
18.3244 mg/l
|
-
|
46 hrs
|
Tetrahymena pyriformis |
Predicted data for target chemical |
4 |
IGC50 |
17 mg/l |
growth inhibition |
48 hrs
|
Tetrahymena pyriformis |
Data from publication for CAS no 93-04-9 |
By applying weight of evidence approach to the studies summarized in the above table it can be observed that IGC50 value is expected to be in the range of 17-108.7335 mg/l in 46 to48 hrs study.
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